Effects of prenatal immune activation and peri-adolescent stress on amphetamine-induced conditioned place preference in the rat
Autor: | Paul S. Horn, Brad Chambers, Jon F. Davis, Rebecca Ahlbrand, Neil M. Richtand, Stephen C. Benoit |
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Rok vydání: | 2011 |
Předmět: |
Male
medicine.medical_treatment media_common.quotation_subject education Conditioning Classical Hippocampus Reversal Learning Disease Article Developmental psychology Rats Sprague-Dawley Pregnancy mental disorders medicine Animals Amphetamine Maze Learning media_common Pharmacology Addiction Extinction (psychology) medicine.disease Conditioned place preference Rats Stimulant Poly I-C Schizophrenia Prenatal Exposure Delayed Effects Female Psychology Stress Psychological medicine.drug |
Zdroj: | Psychopharmacology. 222(2) |
ISSN: | 1432-2072 |
Popis: | Addiction is a disease of learning and memory, as learning processes underlying acquisition, extinction, and reinstatement of drug-paired associations play central roles in addiction. Early developmental stress enhances risk for drug problems in adulthood. Environmental factors influencing learning and memory processes relevant to addiction remain incompletely characterized.To determine effects of prenatal immune activation and developmental stress on conditioned place preference to amphetamine, and reversal learning.Pregnant Sprague-Dawley rats were injected with polyinosinic:polycytidylic acid (poly I:C) or vehicle on gestational day 14. Half of the male offspring received 2 h of restraint stress at post-natal day 35. Behavioral testing was performed in adulthood.Restraint stress inhibited acquisition of place preference to low-dose amphetamine (0.5 mg/kg), while poly I:C treatment had no measurable effect on place preference acquisition. In contrast, drug-induced reinstatement of preference for drug-paired chamber was enhanced in offspring of poly I:C-treated dams [F(1,25)05.31, p00.03]. Performance on a Morris water maze reversal learning task was impaired in poly I:C offspring. Reversal learning performance was correlated with place preference reinstatement in non-stressed (r200.42, p00.0095), but not stressed rats (r2 00.04, p00.49).Prenatal immune activation enhances drug induced reinstatement of conditioned place preference. These data demonstrate longstanding impact on behaviors with potential influence on risk for drug relapse as a consequence of prenatal immune activation. Further study is needed to determine clinical and epidemiological consequences of similar exposures in human populations. |
Databáze: | OpenAIRE |
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