Pineal response to isoproterenol in rats chronically treated with electroconvulsive shock
| Autor: | Palmiero Monteleone, Dargut Kemali, Michela d'Istria, Ismene Serino, B. De Luca, Mario Maj |
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| Přispěvatelé: | Monteleone, P, D'Istria, M, DE LUCA, B, Serino, Ismene, Maj, Mario, Kemali, D. |
| Jazyk: | angličtina |
| Rok vydání: | 1993 |
| Předmět: |
Male
endocrine system medicine.medical_specialty Adrenergic Pineal Gland Pinealocyte Rats Sprague-Dawley Melatonin Pineal gland Internal medicine Isoprenaline Receptors Adrenergic beta medicine Animals Receptor Analysis of Variance Electroshock business.industry General Neuroscience Isoproterenol Rats Endocrinology medicine.anatomical_structure Shock (circulatory) Epilepsy Tonic-Clonic medicine.symptom business Endocrine gland medicine.drug |
| Popis: | Chronic electroconvulsive shock (ECS) has been shown to induce a downregulation of beta 1-adrenergic receptors in the rat cerebral cortex. Because the secretion of melatonin in the pineal gland is regulated primarily by beta 1-adrenoceptors, in the present study we investigated the effect of chronic administration of ECS on pineal beta-adrenergic responsiveness to isoproterenol. To this purpose, young adult male rats received once daily for 8 days ECS (80 mA, 0.5 s) or sham ECS. On the day after the last ECS or sham treatment, they were injected with isoproterenol hydrochloride (1 mg/kg SC) or volume-matched saline at 1600 h. Two hours later they were killed by decapitation. Results showed that the isoproterenol-induced increase in the pineal melatonin content was blunted in rats treated with ECS as compared to sham-treated animals (shock x drug interaction = p < 0.01). These data indicate that chronic ECS treatment affects beta 1 receptor-mediated melatonin production in the pineal gland. Further studies need to elucidate whether the blunted melatonin response to isoproterenol in ECS-treated rats is due to a downregulation of pinealocyte beta-adrenergic receptors. |
| Databáze: | OpenAIRE |
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