Backscatter-difference Measurements of Cancellous Bone Using an Ultrasonic Imaging System
| Autor: | Cameron R. Thurston, Brent K. Hoffmeister, Catherine J. Miller, Morgan R. Smathers, Joseph A. McPherson, P. Luke Spinolo, Sang-Rok Lee |
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| Rok vydání: | 2015 |
| Předmět: |
Adult
Male Materials science Backscatter 01 natural sciences Signal Article 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine 0103 physical sciences Image Processing Computer-Assisted medicine Humans Scattering Radiation Radiology Nuclear Medicine and imaging Time domain 010301 acoustics Aged Ultrasonography Bone mineral Radiological and Ultrasound Technology business.industry Ultrasound Reproducibility of Results Signal Processing Computer-Assisted Middle Aged medicine.anatomical_structure Frequency domain Cancellous Bone Osteoporosis Female Ultrasonic sensor business Cancellous bone Biomedical engineering |
| Zdroj: | Ultrasonic Imaging. 38:285-297 |
| ISSN: | 1096-0910 0161-7346 |
| DOI: | 10.1177/0161734615603703 |
| Popis: | Backscatter-difference measurements may be used to detect changes in bone caused by osteoporosis. The backscatter-difference technique measures the power difference between two portions of an ultrasonic backscatter signal. The goal of this study is to evaluate the feasibility of using an ultrasonic imaging system to perform backscatter-difference measurements of bone. Ultrasonic images and backscatter signals were acquired from 24 specimens of human cancellous bone. The signals were analyzed in the frequency domain to determine the normalized mean backscatter-difference (nMBD) and in the time domain to determine the normalized backscatter amplitude ratio (nBAR). The images were analyzed to determine the normalized pixel value difference (nPVD), which measures the difference in average pixel brightness between regions of interest placed at two different depths in the image. All three parameters were found to increase with bone mineral density. The signal-based parameters, nMBD and nBAR, correlated well with bone mineral density, yielding linear correlation coefficients that ranged from 0.74 to 0.87. The image based parameter, nPVD, performed somewhat less well, yielding correlation coefficients that ranged from 0.42 to 0.81. These results suggest that ultrasonic imaging systems may be used to perform backscatter-difference measurements for the purpose of ultrasonic bone assessment. |
| Databáze: | OpenAIRE |
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