Protective effect of Chuquiraga spinosa extract on N-methyl-nitrosourea (NMU) induced prostate cancer in rats
| Autor: | Oscar Herrera-Calderon, Victor Chumpitaz-Cerrate, Roberto Chávez-Asmat, Jorge Luis Arroyo-Acevedo, Andrea Anampa-Guzmán, Edwin Enciso-Roca |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Nitrosourea Urology Cytotoxicity lcsh:RC870-923 Superoxide dismutase 03 medical and health sciences chemistry.chemical_compound Prostate cancer 0302 clinical medicine Oral administration Internal medicine Chuquiraga spinosa medicine Testosterone biology business.industry Cyproterone acetate Antigenotoxicity Malondialdehyde medicine.disease lcsh:Diseases of the genitourinary system. Urology 030104 developmental biology Endocrinology chemistry 030220 oncology & carcinogenesis biology.protein Original Article Anti-inflammatory Antioxidant business |
| Zdroj: | Prostate International Prostate International, Vol 5, Iss 2, Pp 47-52 (2017) |
| ISSN: | 2287-903X 2287-8882 |
| Popis: | Background: The main objective was to evaluate the possible protective effect of Chuquiraga spinosa extract on N-methyl nitrosourea (NMU)-induced prostate cancer in rats and DU-145 cell line. Materials and methods: Prostate carcinogenesis was induced in 30 male Holtzman rats by providing cyproterone acetate, testosterone, and NMU. The tumors were monitored and hematological and biochemical parameters and frequency of micronucleated polychromatic erythrocytes were recorded. The cell line was assessed by a cytotoxicity assay. Results: Oral administration of C. spinosa extract significantly lowered superoxide dismutase malondialdehyde, NO, C-reactive protein, and prostate-specific antigen levels (all P |
| Databáze: | OpenAIRE |
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