Viral Bacterial Interactions in Children: Impact on Clinical Outcomes
| Autor: | Alejandro Diaz-Diaz, Asuncion Mejias, Cristina Garcia-Maurino, Jeffrey Naples, Octavio Ramilo, Alejandro Jordan-Villegas |
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| Rok vydání: | 2019 |
| Předmět: |
Microbiology (medical)
viruses Respiratory System Respiratory Syncytial Virus Infections Disease Severity of Illness Index Article Virus 03 medical and health sciences 0302 clinical medicine Immune system 030225 pediatrics Severity of illness medicine Humans 030212 general & internal medicine Microbiome Respiratory Tract Infections business.industry Microbiota Infant medicine.disease Pneumonia Infectious Diseases medicine.anatomical_structure Bronchiolitis Child Preschool Respiratory Syncytial Virus Human Pediatrics Perinatology and Child Health Immunology Microbial Interactions business Respiratory tract |
| Zdroj: | Pediatr Infect Dis J |
| ISSN: | 0891-3668 |
| DOI: | 10.1097/inf.0000000000002319 |
| Popis: | Respiratory viral infections are associated with significant morbidity and mortality in children < 5 years of age worldwide. Among all respiratory viruses, respiratory syncytial virus (RSV) is the world’s leading cause of bronchiolitis and pneumonia in young children. There are known populations at risk for severe disease but the majority of children who require hospitalization for RSV infection are previously healthy. Viral and host factors have been associated with the pathogenesis of RSV disease, however, the mechanisms that explain the wide variability in the clinical presentation are not completely understood. Recent studies suggest that the complex interaction between the respiratory microbiome, the host’s immune response and the virus may have an impact on the pathogenesis and severity of RSV infection. In this review, we summarize the current evidence regarding the epidemiologic link, the mechanisms of viral-bacterial interactions, and the associations between the upper respiratory tract microbiome and RSV disease severity. |
| Databáze: | OpenAIRE |
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