Hematologic Effect of cis-Platinum-Bleomycin Therapy
| Autor: | Abraham P. Zimelman, Aaron Miller, Waun Ki Hong, Thomas Najarian |
|---|---|
| Rok vydání: | 1981 |
| Předmět: |
Adult
Male Hemolytic anemia Cancer Research medicine.medical_specialty Pathology Cis-platinum Bleomycin Gastroenterology chemistry.chemical_compound Text mining Internal medicine medicine Humans Basal cell Lymphocytes Prospective Studies Head and neck Prospective cohort study Aged business.industry Anemia Leukopenia General Medicine Middle Aged medicine.disease Oncology chemistry Head and Neck Neoplasms Carcinoma Squamous Cell Drug Therapy Combination Cisplatin business |
| Zdroj: | Oncology. 38:195-197 |
| ISSN: | 1423-0232 0030-2414 |
| DOI: | 10.1159/000225550 |
| Popis: | A prospective study of the hematologic findings in 19 patients receiving cis-platinum (C-P) bleomycin (B) for squamous cell carcinoma of the head and neck was performed. CP 3 mg/kg was given on day 1, B 15 mg/m2 on day 3 and then by continuous infusison from day 3 to 10. Hematocrits declined in all patients from a mean of 41.6 +/- 3.9 to 36.6 +/- 4.9 (p less than 0.001) with the nadir seen by 10 days, reticulocyte count was unchanged. In 1 patient marked hemolysis occurred over 10-day period associated with the appearance of irregular spherocytes on smear, a situation similar to the index case which initiated this study. 5 other patients had spherocytes. A significant lymphopenia in the absence of neutropenia and thrombocytopenia was also observed. |
| Databáze: | OpenAIRE |
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