Cytotoxic Prenylated Xanthones from the Leaves of Garcinia bracteata

Autor:	Zhang Baojun, Hongsheng Tan, Wenwei Fu, Jin-Ling Yang, Bing-Xiong Yan, Rong Wu, Cai-Yun Yao, Hong-Xi Xu, Changwu Zheng, Song Zhijun
Rok vydání:	2019
Předmět:	Xanthones Pharmaceutical Science 01 natural sciences Analytical Chemistry HeLa Structure-Activity Relationship Prenylation Cell Line Tumor Drug Discovery Humans Cytotoxic T cell Structure–activity relationship Cytotoxicity Pharmacology biology Traditional medicine Cytotoxins 010405 organic chemistry Chemistry Organic Chemistry Clusiaceae biology.organism_classification Garcinia bracteata 0104 chemical sciences Plant Leaves 010404 medicinal & biomolecular chemistry Complementary and alternative medicine Cell culture PC-3 Cells Molecular Medicine Garcinia HeLa Cells
Zdroj:	Planta Medica. 85:444-452
ISSN:	1439-0221 0032-0943
DOI:	10.1055/a-0828-9831
Popis:	Six new prenylated xanthones (1–6) and seventeen known xanthones were isolated from extracts of Garcinia bracteata leaves. Their structures were determined by extensive NMR and MS spectroscopic data analysis. The inhibitory activities of the isolates were assayed on HeLa, A549, PC-3, HT-29, and WPMY-1 cell lines. Compounds 1 and 15–17 showed moderate inhibitory effects on tumor cell growth, with IC50s ranging from 3.7 to 14.7 µM.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::935221dba3750033d9289dfc2ac162e1 https://doi.org/10.1055/a-0828-9831 Zobrazit plný text záznamu