Biodegradable, Hydrogen Peroxide, and Glutathione Dual Responsive Nanoparticles for Potential Programmable Paclitaxel Release
| Autor: | Xueyun Wang, Toujun Zou, Daiqin Chen, Guoqiang Zhang, Ying Zhang, Hao Hong, Ruimin Li, Chunying Shu, Li-Jun Wan, Mirong Guan, Chunru Wang |
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| Rok vydání: | 2018 |
| Předmět: |
Male
Thioketal Paclitaxel Polymers Antineoplastic Agents Biodegradable Plastics CHO Cells 02 engineering and technology Sulfides Pharmacology 010402 general chemistry 01 natural sciences Biochemistry Catalysis Mice chemistry.chemical_compound Cricetulus Colloid and Surface Chemistry In vivo Cell Line Tumor Animals Humans Hydrogen peroxide chemistry.chemical_classification Drug Carriers Reactive oxygen species Prostatic Neoplasms Green Chemistry Technology Hydrogen Peroxide General Chemistry Glutathione 021001 nanoscience & nanotechnology Xenograft Model Antitumor Assays 0104 chemical sciences Drug Liberation chemistry Drug delivery Nanoparticles 0210 nano-technology Intracellular |
| Zdroj: | Journal of the American Chemical Society. 140:7373-7376 |
| ISSN: | 1520-5126 0002-7863 |
| DOI: | 10.1021/jacs.7b12025 |
| Popis: | Reactive oxygen species (ROS) and glutathione (GSH) dual responsive nanoparticulate drug delivery systems (nano-DDSs) hold great promise to improve the therapeutic efficacy and alleviate the side effects of chemo drugs in cancer theranosis. Herein, hydrogen peroxide (H2O2) and GSH dual responsive thioketal nanoparticle (TKN) was rationally designed for paclitaxel (PTX) delivery. Compared to other stimuli-sensitive nano-DDSs, this dual responsive DDS is not only sensitive to biologically relevant H2O2 and GSH for on-demand drug release but also biodegradable into biocompatible byproducts after fulfilling its delivering task. Considering the heterogeneous redox potential gradient, the PTX loaded TKNs (PTX-TKNs) might first respond to the extracellular ROS and then to the intracellular GSH, achieving a programmable release of PTX at the tumor site. The selective toxicity of PTX-TKNs to tumor cells with high levels of ROS and GSH was verified both in vitro and in vivo. |
| Databáze: | OpenAIRE |
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