Extent of T cell receptor ligation can determine the functional differentiation of naive CD4+ T cells
| Autor: | Ann Woodard, Theresa Pasqualini, Stephanie L. Constant, Kim Bottomly, Christiane Pfeiffer |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 1995 |
| Předmět: |
CD4-Positive T-Lymphocytes
Male T cell Immunology Dose-Response Relationship Immunologic Receptors Antigen T-Cell Cytochrome c Group Mice Transgenic Biology Moths Interleukin 21 Interferon-gamma Mice Th2 Cells medicine Immunology and Allergy Cytotoxic T cell Animals IL-2 receptor Antigens Antigen-presenting cell Interleukin 3 CD28 Cell Differentiation Articles Th1 Cells Natural killer T cell Molecular biology Peptide Fragments medicine.anatomical_structure Female Interleukin-4 |
| Zdroj: | The Journal of Experimental Medicine |
| ISSN: | 1540-9538 0022-1007 |
| Popis: | Naive CD4+ T cells can differentiate into cells predominantly involved in humoral immunity, known as T helper type 2 cells (Th2), or cells involved in cell-mediated immunity, known as Th1 cells. In this report, we show that priming of CD4+ T cells bearing a transgene-encoded T cell receptor can lead to differentiation into Th1-like cells producing abundant interferon gamma when the cells are exposed to high antigen doses, while low doses of the same peptide induce cells with the same T cell receptor to differentiate into Th2-like cells producing abundant interleukin 4. Thus antigen dose is one factor that can control the differentiation fate of a naive CD4+ T cell. |
| Databáze: | OpenAIRE |
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