Association between FSHR polymorphisms and polycystic ovary syndrome among Chinese women in north China

Autor: Junfen Liu, Xueqing Wu, Suming Xu, Yuanxia Wu, Jing Liu, Xingyu Bi
Rok vydání: 2014
Předmět:
Adult
China
endocrine system
medicine.medical_specialty
endocrine system diseases
Population
Single-nucleotide polymorphism
Genetic polymorphisms
Polymorphism
Single Nucleotide
Follicle-stimulating hormone
Pregnancy
Polymorphism (computer science)
Internal medicine
Obstetrics and Gynaecology
Genotype
Genetics
Humans
Medicine
Genetics(clinical)
Genetic Predisposition to Disease
Allele
education
Alleles
Genetic Association Studies
Polycystic ovary syndrome
Genetics (clinical)
education.field_of_study
Follicle-stimulating hormone receptor
business.industry
Obstetrics and Gynecology
Single nucleotide polymorphisms
General Medicine
Polycystic ovary
female genital diseases and pregnancy complications
Endocrinology
Reproductive Medicine
Receptors
FSH
Female
Follicle Stimulating Hormone
business
Developmental Biology
Zdroj: Journal of Assisted Reproduction and Genetics
ISSN: 1573-7330
1058-0468
DOI: 10.1007/s10815-013-0166-z
Popis: Purpose Polycystic ovary syndrome (PCOS) is a common endocrine disorder disease among women in reproductive-age. Since follicle stimulating hormone (FSH) exerts important biological functions, the association between PCOS and FSH receptor (FSHR) polymorphisms attracts wide attention. The aim of this study was to evaluate whether polymorphisms of FSHR at 307 and 680 codons are associated with PCOS patients in China. Methods Patients with PCOS (n = 215) and controls (n = 205) were recruited from Shanxi Province in north China. They are Han ethnics. Genomic DNA was isolated from the venous blood. The Ala307Thr and Ser680Asn polymorphisms of FSHR were analyzed by polymerase chain reaction–restriction fragment length polymorphism (PCR–RFLP) and direct DNA sequencing. Results The distributions of genotype and allele of Ala307Thr and Ser680Asn polymorphisms of FSHR were not statistically different between the PCOS patients and the controls. Analysis of the frequency of FSHR polymorphisms showed no statistical difference among the PCOS patients with different obesity standards. Although there were no statistical differences in the most of the endocrine parameters including LH, LH/FSH, E2, P and T as well as the clinical pregnancy rate, there were significant differences in the levels of FSH and PRL among PCOS patients carrying different genotypes of Ala307Thr and Ser680Asn polymorphisms. Conclusion The Ala307Thr and Ser680Asn polymorphisms of FSHR are not associated with PCOS in Han ethnic Chinese women in north China. The FSHR polymorphisms was related to the levels of FSH and PRL but not other PCOS-associated endocrine hormones as well as clinical pregnancy rate in PCOS patients of Han Chinese ethnical population.
Databáze: OpenAIRE
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