Intra-familial aggregation and heritability of aortic versus brachial pulse pressure after imputing pretreatment values in a community of African ancestry
| Autor: | Michelle Redelinghuys, Angela J. Woodiwiss, Gavin R. Norton, Olebogeng H.I. Majane, Muzi J. Maseko |
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| Rok vydání: | 2012 |
| Předmět: |
Male
medicine.medical_specialty Brachial Artery Physiology African descent Black People Blood Pressure Internal medicine medicine.artery Internal Medicine medicine Humans Radial artery Aged business.industry Confounding Family aggregation Stroke volume Heritability Middle Aged Surgery Pulse pressure Africa Cardiology Female Three generations Cardiology and Cardiovascular Medicine business |
| Zdroj: | Journal of hypertension. 30(6) |
| ISSN: | 1473-5598 |
| Popis: | AIM To compare the intra-familial aggregation and heritability of central (aortic) (PPc) versus peripheral (brachial) (PPp) pulse pressure after imputing pretreatment blood pressures (BPs) in treated participants in a community of black African ancestry. METHODS Central PPc [generalized transfer function (GTF) and radial P2-derived] was determined with applanation tonometry at the radial artery (SphygmoCor software) in 946 participants from 258 families with 23 families including three generations from an urban developing community of black Africans. In the 24.1% of participants receiving antihypertensive treatment, pretreatment brachial BP was imputed from published overall averaged effects of therapy grouped by class and dose, specific for groups of black African descent. From these data PPc was estimated from proportionate differences in central aortic and brachial PP. Heritability estimates were determined from SAGE software. Echocardiography was evaluated in 507 participants in order to determine stroke volume. RESULTS With adjustments for confounders, parent-child (P |
| Databáze: | OpenAIRE |
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