Antiphospholipid syndrome (APS) in patients with systemic lupus erythematosus (SLE) implies a more severe disease with more damage accrual and higher mortality
| Autor: | Esther Ruiz-Lucea, Esther Uriarte-Isacelaya, Raúl Menor-Almagro, Elena Aurrecoechea, Leyre Riancho-Zarrabeitia, Juan Ovalles, José Ángel Hernández-Beriain, Mercedes Freire-González, Víctor M. Martínez-Taboada, Javier Narváez-García, F. J. Alonso, Jaime Calvo-Alén, Alejandro Olivé-Marqués, Iñigo Rúa-Figueroa, Loreto Horcada, María Galindo-Izquierdo, Carlos Galisteo, Alina Botenau, Eva Tomero-Muriel, Gregorio Santos Soler, Lorena Expósito, Enrique Raya, Antonio Fernández-Nebro, Ivan Castellví, Mariano Andrés, Víctor Quevedo Vila, Mónica Ibáñez-Barcelo, José M. Pego-Reigosa |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
Male Severe disease Rheumatology systemic lupus erythematosus Antiphospholipid syndrome immune system diseases medicine Humans Lupus Erythematosus Systemic In patient Registries skin and connective tissue diseases Retrospective Studies Lupus anticoagulant Antiphospholipid antibody biology business.industry Middle Aged Antiphospholipid Syndrome medicine.disease Organ damage lupus anticoagulant Spain Immunology Antibodies Antiphospholipid biology.protein Regression Analysis Female Antibody business antiphospholipid syndrome |
| Zdroj: | LUPUS r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante instname r-FISABIO: Repositorio Institucional de Producción Científica Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO) r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau r-FISABIO. Repositorio Institucional de Producción Científica r-IIB SANT PAU: Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau Institut dInvestigació Biomèdica Sant Pau (IIB Sant Pau) Lupus r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol |
| ISSN: | 0961-2033 |
| Popis: | Introduction Antiphospholipid antibodies (aPL) have been associated with organ damage and certain features in systemic lupus erythematosus(SLE) patients. Our aim was to investigate the differences between SLE patients according to the presence of aPL and/or clinical antiphospholipid syndrome (APS). Materials and methods Patients from the RELESSER-T registry were included. RELESSER-T is a Spanish multicenter, hospital-based, retrospective, SLE registry. Results We included 2398 SLE patients, 1372 of whom were positive for aPL. Overall 1026 patients were classified as SLE, 555 as SLE-APS and817 as SLE-aPL. Regarding cardiovascular risk factors, SLE-APS patients had higher rates of hypertension, dyslipidemia and diabetes than those with SLE-aPL and SLE ( p Conclusions SLE-APS patients exhibited more severe clinical profiles with higher frequencies of major organ involvement, greater damage accrual and higher mortality than SLE-aPL and SLE patients. |
| Databáze: | OpenAIRE |
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