Increased Oxidative Stress Following Acute and Chronic High Altitude Exposure
| Autor: | Elizabeth Escudero, Robert B. Schoene, George F. Schreiner, Erik R. Swenson, J. Ashley Jefferson, J. Simoni, Richard J. Johnson, Abdias Hurtado, Donald E. Wesson, Maria Elena Hurtado |
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| Rok vydání: | 2004 |
| Předmět: |
Adult
Male medicine.medical_specialty Physiology Acclimatization Hypertension Pulmonary Ventricular Dysfunction Right Polycythemia Altitude Sickness Isoprostanes Hematocrit medicine.disease_cause Thiobarbituric Acid Reactive Substances Dinoprostone Altitude Risk Factors Internal medicine Peru medicine TBARS Humans Hyperoxia F2-Isoprostanes medicine.diagnostic_test business.industry Hemodynamics Public Health Environmental and Occupational Health General Medicine Middle Aged Effects of high altitude on humans Hypoxia (medical) medicine.disease Glutathione Oxidative Stress Chronic mountain sickness Endocrinology Biochemistry Acute Disease Chronic Disease Lipid Peroxidation medicine.symptom business Oxidative stress |
| Zdroj: | High Altitude Medicine & Biology. 5:61-69 |
| ISSN: | 1557-8682 1527-0297 |
| Popis: | The generation of reactive oxygen species is typically associated with hyperoxia and ischemia reperfusion. Recent evidence has suggested that increased oxidative stress may occur with hypoxia. We hypothesized that oxidative stress would be increased in subjects exposed to high altitude hypoxia. We studied 28 control subjects living in Lima, Peru (sea level), at baseline and following 48 h exposure to high altitude (4300 m). To assess the effects of chronic altitude exposure, we studied 25 adult males resident in Cerro de Pasco, Peru (altitude 4300 m). We also studied 27 subjects living in Cerro de Pasco who develop excessive erythrocytosis (hematocrit > 65%) and chronic mountain sickness. Acute high altitude exposure led to increased urinary F(2)-isoprostane, 8-iso PGF(2 alpha) (1.31 +/- 0.8 microg/g creatinine versus 2.15 +/- 1.1, p = 0.001) and plasma total glutathione (1.29 +/- 0.10 micromol versus 1.37 +/- 0.09, p = 0.002), with a trend to increased plasma thiobarbituric acid reactive substance (TBARS) (59.7 +/- 36 pmol/mg protein versus 63.8 +/- 27, p = NS). High altitude residents had significantly elevated levels of urinary 8-iso PGF(2 alpha) (1.3 +/- 0.8 microg/g creatinine versus 4.1 +/- 3.4, p = 0.007), plasma TBARS (59.7 +/- 36 pmol/mg protein versus 85 +/- 28, p = 0.008), and plasma total glutathione (1.29 +/- 0.10 micromol versus 1.55 +/- 0.19, p < 0.0001) compared to sea level. High altitude residents with excessive erythrocytosis had higher levels of oxidative stress compared to high altitude residents with normal hematological adaptation. In conclusion, oxidative stress is increased following both acute exposure to high altitude without exercise and with chronic residence at high altitude. |
| Databáze: | OpenAIRE |
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