Superficial hemosiderosis of the central nervous system
| Autor: | John M. Gomori, S. Honigman, A. Reches, Y. River |
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| Rok vydání: | 1994 |
| Předmět: |
Male
medicine.medical_specialty Hemosiderosis Subarachnoid hemorrhage Iron Astrocytoma Trientine Gastroenterology Central nervous system disease Postoperative Complications Central Nervous System Diseases Recurrence Internal medicine medicine Humans Cerebellar Neoplasms Neurologic Examination biology medicine.diagnostic_test business.industry Magnetic resonance imaging Middle Aged Subarachnoid Hemorrhage medicine.disease Combined Modality Therapy Superficial siderosis Surgery Ferritin Neurology Ferritins biology.protein Neurology (clinical) business Follow-Up Studies Rare disease Hemifacial spasm |
| Zdroj: | Movement Disorders. 9:559-562 |
| ISSN: | 1531-8257 0885-3185 |
| DOI: | 10.1002/mds.870090509 |
| Popis: | Superficial hemosiderosis (SH) of the CNS is a rare disease caused by repeated subarachnoid hemorrhage, with progressive superficial siderosis of the CNS. We report a patient with SH whose clinical picture was marked by progressive gait ataxia, hearing loss, dysarthria, and recurrent episodes of hemifacial spasm. Iron and ferritin levels in the CSF were significantly higher than in a control group of patients. Six month's treatment with the iron-chelating agent trientine dihydrochloride led to clinical improvement, with a concomitant reduction of CSF iron level. We suggest that, in addition to magnetic resonance imaging findings, CSF levels of iron and ferritin should be used as diagnostic criteria for SH, as well as to estimate the efficacy of iron chelation treatment. |
| Databáze: | OpenAIRE |
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