N-(1,1-Dihydroperfluorooctyl)Pyridinium Trifluoromethanesulfonate, a New Quaternary Ammonium Antiseptic
| Autor: | D. C. Kvam, D. M. Updegraff, J. E. Robertson |
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| Rok vydání: | 1970 |
| Předmět: |
Chemical Phenomena
medicine.drug_class Staphylococcus Pharmaceutical Science Pyridinium Compounds Cetylpyridinium chloride chemistry.chemical_compound Blood serum Antiseptic Escherichia coli medicine Organic chemistry Ammonium Candida Aqueous solution Chemistry Streptococcus Aspergillus Distilled water Pseudomonas aeruginosa Anti-Infective Agents Local Pyridinium Trifluoromethanesulfonate Bacillus subtilis Nuclear chemistry |
| Zdroj: | Journal of Pharmaceutical Sciences. 59:188-192 |
| ISSN: | 0022-3549 |
| DOI: | 10.1002/jps.2600590210 |
| Popis: | The synthesis and biological evaluation of N-(1,1-dihydroperfluorooctyl)pyridinium trifluoromethanesulfonate (MBR 3092-42), a highly fluorinated quaternary ammonium antiseptic, are described. The material is structurally related to cetylpyridinium chloride. It shows approximately equivalent bacteriostatic activity to cetylpyridinium chloride but somewhat less fungistatic activity. The bactericidal activity of MBR 3092-42 is slightly less than that of cetylpyridinium chloride in equal concentration in distilled water of in 10% blood serum, but is slightly greater in 80% human blood. MBR 3092-42 is also antibacterially equivalent to cetylpyridinium chloride on the resident bacterial flora of human skin. Although this new compound slowly decomposes in water at pH 7 and above, it is stable in weakly acidic aqueous or hydroalcoholic solutions. Solutions of MBR 3092-42 yield much lower surface tension values than equivalent concentrations of cetylpyridinium chloride. |
| Databáze: | OpenAIRE |
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