| Autor: |
Pérez-Díez, Irene, Hidalgo, Marta R, Barquín, Miguel, Atocha Romero, Farràs, Rosa, García-García, Francisco |
| Rok vydání: |
2019 |
| DOI: |
10.6084/m9.figshare.7981862.v1 |
| Popis: |
Lung cancer is the most common cause of cancer death worldwide, and 85% of patients belongs to a subtype known as non small cell lung cancer. Although it is greatly associated with smoking, several studies have found sex-related epidemiologic differences: lung cancer in never smokers has a higher incidence in women, adenocarcinoma subtype has a higher predominance in women and men show lower survival rates. Understanding these differences in a biology and molecular mechanisms context is crucial for the development of effective therapies and the improvement of lung cancer diagnosis.Our approach starts with a systematic review and selection of omics studies available in public repositories such as Gene Expression Omnibus (GEO) and The Cancer Genome Atlas (TCGA), focusing on microarray and RNA-seq datasets. We have analyzed data in a signaling pathways and molecular functions context from early-stage adenocarcinoma samples comparing between women and men (including control/case information) and applying acorrection for smoking-habits. Finally, we have applied a functional meta-analysis custom R script combining all individual study results, which provides us of better interpretation and higher statistical power.The obtained results allow us to know the altered functions in adenocarinoma between sexes, like the enrichment of immune-response related functions in women, providing us with the opportunity to determine new and more effective therapeutic targets within the framework of precision medicine. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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