Tratamiento antimicrobiano en niños con neutropenia febril de alto riesgo
| Autor: | Milena Villarroel C, Juan Cristóbal Ossa A, María Elena Santolaya Dp, Eliana Muñoz B |
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| Jazyk: | Spanish; Castilian |
| Rok vydání: | 2008 |
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| Zdroj: | Revista chilena de pediatría v.79 n.4 2008 SciELO Chile CONICYT Chile instacron:CONICYT |
| Popis: | Antibiotic treatment in children with High Risk Febrile Neutropenia Background: In children with cancer and high risk febrile neutropenia (HRFN), the initial empiricaltreatment used in our hospital for 5 years includes the association of Cloxacillin + Ceftazidime + Amikacin.There is no chilean literature that reviews the effectiveness of this therapy. Objective: Evaluate the clinicaland microbiological effectiveness of this associated therapy in children with HRFN. Method: A prospective-descriptive study evaluating children with HRFN admitted at Hospital Luis Calvo Mackenna betweenJanuary 2005-August 2006. Results: 100 HRFN episodes were evaluated. In 48% of cases, the antimicrobialtreatment was considered effective, whereas in 52% of episodes the therapy required modifications (15%cases within the first 72 hours). The most frequent diagnoses were fever without clinical focus (51%) andsepsis (13%). 36% had microbiological identification and the most frequently isolated bacteria wereEscherichia coli (9%) and Staphylococcus aureus (9%). Conclusions: A favorable answer with the initialempirical therapy was obtained for 48% of cases; meanwhile in the remaining episodes, 28% requiredantibiotics modifications without justification. This fact remarks the importance of following the establishedguidelines for antimicrobial treatment modification in these patients.(Key words: Cancer, febrile neutropenia, antibiotics, oncology).Rev Chil Pediatr 2008; 79 (4): 381-387RESUMENIntroduccion: En los ninos con cancer y netropenia febril (NF) de alto riesgo, se utiliza en nuestro centrohace 5 anos, como esquema empirico inicial, la asociacion de ceftazidima-amikacina-cloxacilina. No hayliteratura nacional que analice la eficacia de este esquema. Objetivo: Evaluar la eficacia clinica y microbiologicade la asociacion de ceftazidima, amikacina y cloxacilina en ninos con NF de alto riesgo. Metodo: Protocolodescriptivo, prospectivo. Evaluar ninos con NF de alto riesgo hospitalizados en el HLCM entre enero 2005 |
| Databáze: | OpenAIRE |
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