The effects of trazodone on sleep disturbances induced by brofaromine
| Autor: | M.S. Vos, P.M.J. Haffmans |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Monoamine Oxidase Inhibitors
medicine.drug_class Sleep REM Placebo law.invention Hypnotic 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Randomized controlled trial Double-Blind Method Piperidines law Sleep Initiation and Maintenance Disorders Brofaromine Insomnia medicine Humans Wakefulness Slow-wave sleep Sleep disorder Dose-Response Relationship Drug business.industry Trazodone Electroencephalography medicine.disease 030227 psychiatry Psychiatry and Mental health chemistry Anesthesia medicine.symptom business 030217 neurology & neurosurgery Selective Serotonin Reuptake Inhibitors medicine.drug Follow-Up Studies |
| Zdroj: | European psychiatry : the journal of the Association of European Psychiatrists. 14(3) |
| ISSN: | 0924-9338 |
| Popis: | SummaryThe effects of trazodone on subjective and objective sleep parameters were compared to those of placebo in a double-blind design in seven patients who developed insomnia during treatment with the selective and reversible MAO-A inhibitor, brofaromine. Trazodone significantly increased deep sleep and altered the architecture of sleep in these patients. Subjectively, patients reported a better and deeper sleep. No negative interactions between brofaromine and trazodone were observed and side-effects were minimal. A low dose of trazodone may be a safe and effective agent in the treatment of MAO-I induced insomnia. |
| Databáze: | OpenAIRE |
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