Association between meniscal volume and development of knee osteoarthritis
Autor: | Edwin H.G. Oei, Dawei Xu, Sebastia Margaretha Agatha Bierma-Zeinstra, Jos Runhaar, Femke Wagner, Jan A van der Voet, Stefan Klein, Nils M Hansson |
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Přispěvatelé: | General Practice, Radiology & Nuclear Medicine, Medical Informatics, Orthopedics and Sports Medicine |
Rok vydání: | 2020 |
Předmět: |
musculoskeletal diseases
Radiography Osteoarthritis meniscal volume Knee Joint Meniscus (anatomy) Asymptomatic knee osteoarthritis Body Mass Index 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine RC925 Rheumatology RC927 Synovitis medicine Humans Meniscus Pharmacology (medical) Obesity Arthrography AcademicSubjects/MED00360 030203 arthritis & rheumatology medicine.diagnostic_test business.industry Cartilage Magnetic resonance imaging Middle Aged Osteoarthritis Knee Overweight Clinical Science musculoskeletal system medicine.disease Magnetic Resonance Imaging medicine.anatomical_structure Female medicine.symptom business Nuclear medicine MRI |
Zdroj: | Rheumatology (Oxford, England) Rheumatology (United Kingdom), 60(3), 1392-1399. Oxford University Press |
ISSN: | 1462-0332 1462-0324 |
Popis: | The diagnosis of OA is mainly based on symptoms and radiographic features. Since 1986, ACR criteria have been used to classify knee OA [1]. More recently, MRI has been shown to have a higher sensitivity in detecting structural knee OA, especially when compared with Kellgren and Lawrence (K&L) grading on weight-bearing posterior-anterior flexed knee radiographs [2]. Several studies indicated that MRI is able to detect early OA features in asymptomatic persons without radiographic knee OA [3, 4]. Radiographic abnormalities in OA have been described extensively, including joint space narrowing (JSN), sclerosis of subchondral bone and the presence of osteophytes. Compared with the surrogate measurement of JSN on radiographic images, MRI enables direct evaluation of the cartilage, which is the main abnormality in OA. Therefore, the MRI holds promise as an alternative to radiography in the evaluation of joint structure [5], although until now there has been no consensus or a standardized scoring system for knee OA, especially in quantitative MRI-based measurement. It is widely accepted that a strong causal relationship between meniscal damage and structural progression of OA exists [6]. A meniscal pathway to knee OA was implicated by a loss of meniscal function due to damage or extrusion, leading to increased biomechanical stress in the knee joint. This stress results in damage such as cartilage loss, subchondral bone changes, bone marrow lesions and synovitis, eventually resulting in symptomatic OA [7]. In view of this significant pathway in the pathogenesis of OA, it is important to assess the presence of meniscal pathologies, especially when studying early-stage knee OA. To better understand the meniscal changes, previous studies described meniscal constructs such as volume, extrusion, thickness (height) and tibial coverage [8–10]. In a recent study, we confirmed an independent association between meniscal extrusion and the development of knee OA in overweight and obese women [11]. However, extrusion was scored semi-quantitatively using MRI Osteoarthritis Knee Score (MOAKS) [12], which does not consider the absolute sizes of both tibial plateau and meniscus, and the percentage of tibial cartilage covered by the meniscus. The quantification of meniscal volume has been explored by segmentation of MRI images to obtain 3D volumetric morphometry. However, until now, there are still conflicting results on the association between meniscal volume and incident knee OA [13–15]. In this study, we therefore evaluated the association between both baseline meniscal volume and its longitudinal change and incident knee OA among middle-aged, overweight and obese women. By quantitatively analysing meniscal volume for those who are at high risk for OA development, we tried to determine whether meniscal volume could be a biomarker for incident knee OA. |
Databáze: | OpenAIRE |
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