| Autor: |
Ji-Qun Yang, Jie Jia, Yu Zhao, Wei-Jie Wang, Tong Chen, Ying-Rong Du, Gui-Fang Hu, Jun Li, Ming-Chun Wang, Yi-Qun Kuang |
| Rok vydání: |
2022 |
| Předmět: |
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| DOI: |
10.21203/rs.3.rs-2067581/v1 |
| Popis: |
Background: Hypertension patients with drug use have a low susceptibility to hypotensor. The pathogenesis and metabolic characteristics of hypertension in drug users remain unknown. Methods: We performed high-throughput sequencing for transcriptome and metabolome of peripheral blood from 30 hypertension patients with drug use (HBP-DU) and 30 hypertension patients without drug use (HBP). Results: Differentially expressed genes (DEGs) between the HBP and HBP-DU groups were mainly involved in the pathways of toll-like receptor (TLR) cascades, FCERI signaling, and interleukin signaling. Differentially metabolites (DMs) were significantly enriched in the pathways of alanine and histidine metabolism. We identified a gene cluster (turquoise module, MEturquoise) correlated with the HBP-DU group, which has a similar function to DEGs. The abundance of CD4+ T cells and CD8+ T cells was significantly decreased in the HBP-DU group. Conclusions: These results indicated a potential function of histidine, immune cells, and the pathway of toll-like receptor cascades in drug use hypertension. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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