Association between chronic kidney disease and carotid intima-media thickness in relation to circulating CD34-positive cell count among community-dwelling elderly Japanese men
| Autor: | Hideaki Kondo, Yuji Shimizu, Kairi Kiyoura, Shoichi Fukui, Takahiro Maeda, Yuko Noguchi, Jun Koyamatsu, Shin-ya Kawashiri, Hirotomo Yamanashi, Mami Tamai, Mako Nagayoshi |
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| Rok vydání: | 2019 |
| Předmět: |
Male
0301 basic medicine medicine.medical_specialty T-Lymphocytes Cardiovascular risk factors Endothelial repair Antigens CD34 030204 cardiovascular system & hematology Carotid Intima-Media Thickness 03 medical and health sciences 0302 clinical medicine Japan Risk Factors Internal medicine medicine Humans Lymphocyte Count Renal Insufficiency Chronic Progenitor cell Aged Cd34 positive cell business.industry Incidence Odds ratio Middle Aged Atherosclerosis medicine.disease Confidence interval Cross-Sectional Studies 030104 developmental biology Intima-media thickness Independent Living Cardiology and Cardiovascular Medicine business Biomarkers Kidney disease |
| Zdroj: | Atherosclerosis. 283:85-91 |
| ISSN: | 0021-9150 |
| DOI: | 10.1016/j.atherosclerosis.2019.02.004 |
| Popis: | Background and aims Endothelial injury is well-known as a process that can lead to chronic kidney disease (CKD) and atherosclerosis. Hematopoietic activity is known to be associated inversely with CKD and positively with atherosclerosis. Since bone-derived progenitor cells (CD34-positive cells) contribute to endothelial repair (including the progression of atherosclerosis), understanding the association between CKD and carotid intima-media thickness (CIMT), in relation to circulating CD34-positive cell count, may be an efficient means of clarifying the mechanisms underlying endothelial activity. Methods We conducted a cross-sectional study of 570 elderly Japanese men aged 60–69 years, who underwent a general health check-up. Participants were stratified as per a median circulating CD34-positive cell count (1.01 cells/μL). Results Independent of the known cardiovascular risk factors, CIMT was found to be positively associated with CKD in the participants with high circulating CD34-positive cell counts but not in participants with low counts. Odds ratios were 1.40 (1.04, 1.89) for participants with high and 1.01 (0.72, 1.43) for participants with low circulating CD34-positive cell counts after adjustment for known cardiovascular risk factors at 95% confidence intervals for CKD with one standard deviation increment of CIMT. Conclusions A positive association between CIMT and CKD was observed among participants with high circulating CD34-positive cell counts but not among participants with low counts. Endothelial repair activity might determine the association between CKD and CIMT. |
| Databáze: | OpenAIRE |
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