Grading The Severity Of Obstruction In Mixed Obstructive-Restrictive Lung Disease
| Autor: | Gregg L Ruppel, David A. Kaminsky, Zechariah S. Gardner |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Pulmonary and Respiratory Medicine
Adult Male medicine.medical_specialty macromolecular substances urologic and male genital diseases Critical Care and Intensive Care Medicine Severity of Illness Index Pulmonary function testing Internal medicine Forced Expiratory Volume Severity of illness medicine Humans Lung volumes Restrictive lung disease Lung Diseases Obstructive Intensive care medicine Grading (tumors) Asthma Aged COPD business.industry Total Lung Capacity respiratory system Middle Aged medicine.disease Obstructive lung disease respiratory tract diseases nervous system Practice Guidelines as Topic Cardiology Female Radiology Cardiology and Cardiovascular Medicine business |
| Zdroj: | A64. PULMONARY FUNCTION ASSESSMENT AND OUTCOMES: WRESTLING WITH QUALITY CONTROL. |
| DOI: | 10.1164/ajrccm-conference.2010.181.1_meetingabstracts.a2107 |
| Popis: | The severity of obstructive pulmonary disease is determined by the FEV(1) % predicted based on the American Thoracic Society/European Respiratory Society (ATS/ERS) guidelines. In patients with coexisting restrictive lung disease, the decrease in FEV(1) can overestimate the degree of obstruction. We hypothesize that adjusting the FEV(1) for the decrease in total lung capacity (TLC) results in a more appropriate grading of the severity of obstruction.We examined a large pulmonary function test database and identified patients with both restrictive (TLC80% predicted) and obstructive (FEV(1)/FVCthe lower limit of normal) lung disease. FEV(1) % predicted was adjusted for the degree of restriction by dividing it by TLC % predicted. We compared the distribution of severity grading between adjusted and unadjusted values according to ATS/ERS criteria and determined how the distribution of severity would change based on asthma and COPD guidelines.We identified 199 patients with coexisting restrictive and obstructive lung disease. By ATS/ERS grading, the unadjusted data categorized 76% of patients as having severe or very severe obstruction and 11% as having mild or moderate obstruction. The adjusted data classified 33% with severe or very severe obstruction and 44% with mild or moderate obstruction. Of the corrected values, 83% resulted in a change to less severe obstruction by ATS/ERS guidelines, and 44% and 70% of patients, respectively, would be reclassified as having less severe obstruction by current asthma and COPD guidelines.This method results in a more appropriate distribution of severity of obstruction, which should lead to more accurate treatment of obstruction in these patients. |
| Databáze: | OpenAIRE |
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