Clonal identity between skin and synovial tissue in a case of mycosis fungoides with polyarthritis
| Autor: | Anton W. Langerak, King H. Lam, M'hamed El Abdouni, Pieternella J. Lugtenburg, F. Heule, Radboud J.E.M Dolhain, Yorick Sandberg |
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| Přispěvatelé: | Immunology, Pathology, Hematology, Rheumatology, Dermatology |
| Rok vydání: | 2004 |
| Předmět: |
Male
musculoskeletal diseases Pathology medicine.medical_specialty Population Arthritis Dermatology Gene Rearrangement T-Lymphocyte Arthritis Rheumatoid Fatal Outcome Mycosis Fungoides Humans Medicine education Mycosis Skin education.field_of_study Mycosis fungoides business.industry Synovial Membrane Sequence Analysis DNA Middle Aged Hand medicine.disease Peripheral T-cell lymphoma Clone Cells Radiography medicine.anatomical_structure Rheumatoid arthritis Polyarthritis Synovial membrane business |
| Zdroj: | Journal of the American Academy of Dermatology, 51, 111-117. Mosby Inc. |
| ISSN: | 0190-9622 |
| DOI: | 10.1016/j.jaad.2004.01.043 |
| Popis: | Polyarthritis in the presence of a cutaneous T-cell lymphoma is a rare phenomenon. We describe a case of mycosis fungoides with development of a symmetric erosive polyarthritis of the small hand joints and feet, diagnosed as rheumatoid arthritis. An identical monoclonal T-cell population in the skin and in the synovium was detected by T-cell receptor gene rearrangement analysis, illustrating articular dissemination of lymphoma cells. Differentiating mycosis fungoides–associated arthritis from rheumatoid arthritis may have important implications for treatment. Based on this case, the relevant literature, and the newest disease concepts, pathogenic mechanisms and therapeutic options of mycosis fungoides–associated arthritis are discussed. |
| Databáze: | OpenAIRE |
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