Regulation of serum apolipoprotein E metabolism: role of chylomicron metabolism
| Autor: | Paul S. Roheim, Brian R. Krause, John G. Delamatre |
|---|---|
| Rok vydání: | 1982 |
| Předmět: |
Apolipoprotein E
Male medicine.medical_specialty medicine.medical_treatment Lipoproteins VLDL Cholesterol Dietary chemistry.chemical_compound High-density lipoprotein Apolipoproteins E Internal medicine Chylomicrons medicine Animals Saline Triglycerides Meal Multidisciplinary Cholesterol digestive oral and skin physiology Rats Inbred Strains Metabolism Dietary Fats Rats Endocrinology Apolipoproteins chemistry Biochemistry Low cholesterol lipids (amino acids peptides and proteins) Lipoproteins HDL Chylomicron Research Article |
| Zdroj: | Proceedings of the National Academy of Sciences of the United States of America. 79(4) |
| ISSN: | 0027-8424 |
| Popis: | The mechanism by which high-fat, high-cholesterol diets lower serum apolipoprotein E (apoE) concentration was studied in rats by feeding a single high-fat, high-cholesterol meal and by intravenously infusing chylomicrons containing low and high amounts of cholesterol. Serum apoE concentrations were unchanged 9 hours after an olive oil meal but were decreased by 35% after an olive oil/cholesterol-enriched meal. The decrease in serum apoE concentrations with the olive oil/cholesterol meal was accompanied by a decrease in apoE concentration in the high density lipoprotein fraction. Three hours after the intravenous infusion of cholesterol-enriched chylomicrons, serum apoE concentrations decreased 40%, whereas serum apoE concentrations decreased by only 10% when chylomicrons with low cholesterol concentrations or saline were infused. It is concluded that the metabolism of cholesterol-enriched chylomicrons results in an increased removal of serum apoE and that the cholesterol content of chylomicrons is a determinant of serum apoE removal. |
| Databáze: | OpenAIRE |
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