Relationship between autoantibody clustering and clinical subsets in SLE: cluster and association analyses in Hong Kong Chinese
| Autor: | Sik Nin Wong, Chun Yin Chong, Philip H. Li, Raymond Woon Sing Wong, Niko Kei Chiu Tse, Wai Ming Lai, Tsz Leung Lee, Chak Sing Lau, KW Lee, Shirley King Yee Ying, Yu-Lung Lau, Wilfred Hing Sang Wong, Pamela Pui Wah Lee, Chi Chiu Mok, Kwok Lung Tong, Marco Ho, Mo Yin Mok, Tak Mao Chan, Wanling Yang, Alexander Moon Ho Leung, Samuel Ka Shun Fung |
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| Rok vydání: | 2012 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Cross-sectional study Arthritis Young Adult Asian People Rheumatology Epidemiology Prevalence medicine Cluster Analysis Humans Lupus Erythematosus Systemic Pharmacology (medical) Autoantibodies Retrospective Studies Genetic association Lupus erythematosus business.industry Autoantibody medicine.disease Cross-Sectional Studies Antibodies Antinuclear Immunology Hong Kong Female medicine.symptom business Malar rash Serositis |
| Zdroj: | Rheumatology. 52:337-345 |
| ISSN: | 1462-0332 1462-0324 |
| Popis: | Objective This study aims to identify the existence of, and relationship between autoantibody clusters and clinical subsets in Chinese SLE patients. Methods Data from 1928 SLE patients from Hong Kong were analysed. Using cluster analysis, patients were grouped by autoantibodies into clusters. The frequencies of various clinical manifestations were then compared between each cluster. Separate association analyses between individual autoantibodies and clinical manifestations as well as between clinical manifestations were also performed without any prior clustering. Results Three separate autoantibody clusters were identified, each with significantly different clinical manifestations. Cluster 1 was characterized by anti-dsDNA and the greatest prevalence of renal disorder but the lowest frequencies of other clinical manifestations. Cluster 2 was represented by the predominance of anti-Smith, anti-RNP and aPL, with greater prevalence of malar rash, oral ulcers, arthritis and serositis. Cluster 3 was characterized by anti-Ro and anti-La with greater prevalence of discoid rash, photosensitivity and haematological involvement. Individual association analysis also revealed similar findings. Patients of clusters 2 and 3 were more closely related, while cluster 1 was more distinct, associated with renal disorder only and negatively associated or not associated with other manifestations. Conclusion We conclude that autoantibody clustering and clinical subsets exist in SLE patients of our locality. These clusters may be viewed as a bipolar spectrum of related autoantibody and clinical manifestations. At one end are patients with over-representation of anti-dsDNA and renal disorder, while at the other end are two distinct autoantibody clusters (anti-Sm/anti-RNP/aPL and anti-Ro/anti-La) with overlapping of other clinical manifestations. |
| Databáze: | OpenAIRE |
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