The efficacy of fractional carbon dioxide laser combined with narrow-band ultraviolet B phototherapy for non-segmental vitiligo: a systematic review and meta-analysis
| Autor: | Moon Kyun Cho, Woo Il Kim, Sooyoung Kim, Sanghoon Lee |
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| Rok vydání: | 2020 |
| Předmět: |
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medicine.medical_specialty medicine.medical_treatment Vitiligo Dermatology law.invention 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine Combined treatment Randomized controlled trial law Humans Medicine skin and connective tissue diseases Clinical Trials as Topic Co2 laser integumentary system Pigmentation business.industry Dermabrasion Ultraviolet b 030206 dentistry Carbon dioxide laser medicine.disease Combined Modality Therapy Patient Satisfaction Meta-analysis Lasers Gas Ultraviolet Therapy Surgery business Publication Bias |
| Zdroj: | Lasers in Medical Science. 36:165-173 |
| ISSN: | 1435-604X 0268-8921 |
| DOI: | 10.1007/s10103-020-03069-0 |
| Popis: | Fractional carbon dioxide (CO2) laser has been used with conventional treatments for vitiligo, demonstrating more effectiveness compared with conventional treatments alone. Especially, fractional CO2 laser combined with narrow-band ultraviolet B (NB-UVB) was shown to induce more improvement compared with NB-UVB monotherapy for treating stable non-segmental vitiligo. However, the effectiveness of fractional CO2 laser plus NB-UVB for the treatment of non-segmental vitiligo remains controversial. Therefore, this study aimed to confirm the safety and efficacy of fractional CO2 laser combined with NB-UVB compared with NB-UVB monotherapy in stable non-segmental vitiligo. We searched the data from different databases, including Cochrane, Embase, and PubMed up to January 2020. Four randomized controlled trials (RCTs) for comparison between fractional CO2 laser plus NB-UVB and NB-UVB monotherapy in patients with stable non-segmental vitiligo were included. We performed meta-analyses for repigmentation improvement and patient satisfaction as well as subgroup analyses based on acral or non-acral vitiligo, according to the PRISMA guidelines. The combination treatment showed more superior results than NB-UVB monotherapy (≥ 75% repigmentation, RR 4.60, 95% CI 1.19–17.74; ≥ 50% repigmentation, RR 2.24, 95% CI 0.45–11.17 |
| Databáze: | OpenAIRE |
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