Factors determining recovery during nutritional therapy of persistent diarrhoea: the impact of diarrhoea severity and intercurrent infections
| Autor: | Zulfiqar A Bhutta, S. Thobani, Sobia Nizami, Z. Issani |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
Diarrhea
medicine.medical_specialty Pediatrics Diet therapy Sepsis Enteral Nutrition Internal medicine medicine Humans Medical nutrition therapy Risk factor Plants Medicinal business.industry Infant Fabaceae Oryza General Medicine Odds ratio medicine.disease Yogurt Survival Analysis Confidence interval Logistic Models Treatment Outcome Child Preschool Pediatrics Perinatology and Child Health Chronic Disease Diarrhea Infantile Vomiting medicine.symptom business Energy Intake |
| Zdroj: | Acta paediatrica (Oslo, Norway : 1992). 86(8) |
| ISSN: | 0803-5253 |
| Popis: | The recovery pattern and outcome were analysed in 261 consecutive children (age 6-36 months) with persistent diarrhoea who underwent inpatient nutritional rehabilitation with a rice-lentil (Khitchri) and yoghurt-based diet. Overall, 217 (83%) recovered successfully, as judged by a reduction in stool output and weight gain for a consecutive 3 d. Failures were more commonly febrile at admission [odds ratio (OR) 2.3, 95% confidence interval (CI) 1.1-4.8] and a greater number had culture-proven sepsis (Fisher's exact test, p0.001). Logistic regression analysis identified significantly increased risk of treatment failure with several admission characteristics, including stool frequency5 d(-1) (OR 2.9, 95% CI 1.6-5.2), vomiting (OR 2.5, 95% CI 1.1-5.7) and sepsis (OR 2.8, 95% CI 1.1-7.5). Survival analysis revealed significantly longer time-to-recovery among children with stool frequency5 d(-1) at admission (p0.001), suspected sepsis necessitating intravenous antibiotics (p0.001) or oral candidiasis (p0.05). These findings suggest that severity of diarrhoea and coexisting systemic infections are key determinants of the response to nutritional therapy in children with persistent diarrhoea. |
| Databáze: | OpenAIRE |
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