Stable gastric pentadecapeptide BPC 157 heals rat colovesical fistula
| Autor: | Antonio Kokot, Anita Zenko Sever, Sven Seiwerth, Domagoj Drmic, Igor Petrović, Tihomir Grgic, Predrag Sikiric, Dora Grgic, Robert Klicek, Mario Sucic, Marko Sever |
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| Rok vydání: | 2016 |
| Předmět: |
Male
Colovesical fistula medicine.medical_specialty Time Factors Colon medicine.medical_treatment Fistula Adhesion (medicine) Tissue Adhesions 030226 pharmacology & pharmacy 03 medical and health sciences 0302 clinical medicine Fecaluria Intestinal Fistula medicine Animals Rats Wistar Saline Pharmacology Wound Healing Protein Stability BPC 157 colon colovesical fistula healing rats business.industry Anti-ulcer Agent Proteins Anti-Ulcer Agents medicine.disease Peptide Fragments Rats Surgery Defecation 030211 gastroenterology & hepatology business Wound healing |
| Zdroj: | European Journal of Pharmacology. 780:1-7 |
| ISSN: | 0014-2999 |
| Popis: | To establish the effects of BPC 157 on the healing of rat colovesical fistulas, Wistar Albino male rats were randomly assigned to different groups. BPC 157, a stable gastric pentadecapeptide, has been used in clinical applications-specifically, in ulcerative colitis-and was successful in treating both external and internal fistulas. BPC 157 was provided daily, perorally, in drinking water (10µg/kg, 12ml/rat/day) until sacrifice or, alternatively, 10µg/kg or 10ng/kg intraperitoneally, with the first application at 30min after surgery and the last at 24h before sacrifice. Controls simultaneously received an equivolume of saline (5.0ml/kg ip) or water only (12ml/rat/day). Assessment (i.e., colon and vesical defects, fistula leaking, fecaluria and defecation through the fistula, adhesions and intestinal obstruction as healing processes) took place on days 7, 14 and 28. Control colovesical fistulas regularly exhibited poor healing, with both of the defects persisting ; continuous fistula leakage ; fecaluria and defecation through the fistula ; advanced adhesion formation ; and intestinal obstruction. By contrast, BPC 157 given perorally or intraperitoneally and in µg- and ng-regimens rapidly improved the whole presentation, with both colon and vesical defects simultaneously ameliorated and eventually healed. The maximal instilled volume was continuously raised until it reached the values of healthy rats, there were no signs of fecaluria and no defecation through the fistula, there was counteraction of advanced adhesion formation or there was an intestinal obstruction. In conclusion, BPC 157 effects appear to be suited to inducing full healing of colocutaneous fistulas in rats. |
| Databáze: | OpenAIRE |
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