Virus-specific antibodies to Epstein-Barr virus, varicella-zoster virus and rubella virus in renal transplant patients with cytomegalovirus infections
| Autor: | Praful V. Shirodaria, Hugh J. O'Neill |
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| Rok vydání: | 1992 |
| Předmět: |
Microbiology (medical)
Herpesvirus 3 Human Herpesvirus 4 Human viruses Congenital cytomegalovirus infection medicine.disease_cause Antibodies Viral Rubella Herpesviridae Virus Serology Betaherpesvirinae Antibody Specificity Recurrence hemic and lymphatic diseases Medicine Humans Antigens Viral biology business.industry Varicella zoster virus virus diseases Rubella virus medicine.disease biology.organism_classification Virology Kidney Transplantation Infectious Diseases Immunoglobulin M Immunoglobulin G Immunology Cytomegalovirus Infections Capsid Proteins business |
| Zdroj: | The Journal of infection. 24(3) |
| ISSN: | 0163-4453 |
| Popis: | Summary Renal transplant patients with primary and recurrent cytomegalovirus (CMV) infection had higher antibody titres to Epstein-Barr virus viral capsid antigen (EBV-VCA-IgG) before and after transplantation than healthy blood donors. The geometric mean titres (GMT) of EBV-VCA-IgG were higher in renal transplant patients without CMV infection than in renal transplant patients with CMV infection. Four-fold or greater rises in EBV-VCA-IgG antibody were detected in six patients and a similar rise in antibody to EBV early antigen (EBV-EA-IgG) was detected in one other patient. IgM antibody to EBV-VCA (EBV-VCA-IgM) was detected in only three of these patients. EBV-EA-IgG was present in 39% patients and in 30% control subjects. IgG titres to varicella zoster virus (VZV-IgG) and rubella virus (rubella HI) were higher in patients without CMV infection compared to the patients with CMV infection. Raised titres were detected to VZV in five patients and to rubella virus in three patients. Reductions in antibody titre of four-fold or more were also detected in EBV-EA-IgG (one patient) and to rubella virus (one patient). Raised antibody titres to EBV, VZV, and rubella virus in renal transplant patients may indicate reactivation of these viruses without any symptoms. |
| Databáze: | OpenAIRE |
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