Life events, first depression onset and the serotonin transporter gene
| Autor: | Ian P. Blair, Anna Scimone, Heather Niven, Gordon Parker, Philip B. Mitchell, Kay Wilhelm, Peter R. Schofield, Lucinda Wedgwood, Adam Finch |
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| Rok vydání: | 2006 |
| Předmět: |
Oncology
Adult Male medicine.medical_specialty Genotype Neurotic Disorders Genetic determinism Life Change Events 03 medical and health sciences 0302 clinical medicine Sex Factors Risk Factors Internal medicine medicine Humans Genetic Predisposition to Disease 030212 general & internal medicine Parent-Child Relations Adverse effect Psychiatry Gene Serotonin transporter Depression (differential diagnoses) Serotonin Plasma Membrane Transport Proteins Depressive Disorder Major biology Neuroticism Object Attachment 030227 psychiatry Psychiatry and Mental health Logistic Models Cohort biology.protein Female Psychology Follow-Up Studies |
| Zdroj: | The British journal of psychiatry : the journal of mental science. 188 |
| ISSN: | 0007-1250 |
| Popis: | BackgroundA relationship between the serotonin transporter gene, adverse events and onset of major depression has been reported.AimsTo replicate a gene × environment interaction in a cohort with longitudinal data for life events, experience of depression, parental bonding and neuroticism.MethodAtthe 25-year follow-up, genomic DNA was obtained from 127 cohort members (mean age 48 years) to determine the genotype of the serotonin transporter gene-linked promoter region (5-HTTLPR). Associations were investigated between the 5-HTTLPR genotype, positive and adverse life events and the gene × environment interaction, and also between the 5-HTTLPR genotype and risk factors for depression.ResultsNo relationship was found between 5-HTTLPR genotype and either risk factors for depression or positive life events. Adverse life events had a significantly greater impact on the onset of depression for individuals with the s/s genotype.ConclusionsThe 5-HTTLPR genotype is a significant predictor of onset of major depression following multiple adverse events. This is one of the more robust findings concerning specific biological risk factors for depression. |
| Databáze: | OpenAIRE |
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