The decrease in cytokine concentration during albumin dialysis correlates with the prognosis of patients with acute on chronic liver failure
| Autor: | Marcello Candelli, Roberto Flore, C. Di Campli, Marialuisa Novi, Paolo Pola, Maria Assunta Zocco, Angelo Santoliquido, Giovanni Gasbarrini, R. Gaspari, Rodolfo Proietti, Paolo Tondi, Antonio Gasbarrini |
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| Rok vydání: | 2005 |
| Předmět: |
Adult
Male medicine.medical_specialty Pathology Bilirubin medicine.medical_treatment Gastroenterology Proinflammatory cytokine chemistry.chemical_compound Ammonia Renal Dialysis Internal medicine medicine Humans Dialysis Diminution Transplantation business.industry Tumor Necrosis Factor-alpha Interleukins Settore MED/09 - MEDICINA INTERNA Albumin Interleukin Liver Failure Acute Middle Aged Cytokine chemistry Child Preschool Chronic Disease Cytokines Surgery Female Sorption Detoxification The decrease in cytokine concentration business Liver Failure |
| Zdroj: | Transplantation proceedings. 37(6) |
| ISSN: | 0041-1345 |
| Popis: | Background and aim. The clearance of plasma cytokines by means of albumin dialysis (MARS) has been demonstrated in various studies involving patients affected by either acute liver failure (ALF) or acute on chronic liver failure. The aim of the study was to measure the plasma levels of TNF-a, IL-6, and IL-1β in patients with ALF after each MARS treatment to evaluate the relationship between variations in cytokines levels and patient prognosis. Materials and methods. Ten patients with ALF undergoing several MARS treatments were enrolled (group 1). Blood samples were collected before and after each MARS treatment to measure TNF-a, IL-6, and IL-1β, and other hematochemical parameters. We also enrolled 10 patients with ALF who underwent standard therapy (group 2) as well as a control group of 10 healthy subjects matched for sex and age (group 3). Results. MARS reduced total bilirubin levels, biliary acids, BUN, ammonia, TNF-a, IL-6, and IL-lp (P |
| Databáze: | OpenAIRE |
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