Prevention of Oxygen Inhibition of PolyHIPE Radical Polymerization Using a Thiol-Based Cross-Linker
| Autor: | Madison A.P. McEnery, Elizabeth Cosgriff-Hernandez, Jennifer L. Robinson, Hannah A. Pearce, Melissa C. Stuebben, Michael Whitely |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
chemistry.chemical_classification
Materials science Oxygen inhibition Radical polymerization Biomedical Engineering chemistry.chemical_element 02 engineering and technology 010402 general chemistry 021001 nanoscience & nanotechnology Macromonomer 01 natural sciences Oxygen Pentaerythritol Article 0104 chemical sciences Biomaterials chemistry.chemical_compound Chemical engineering Polymerization chemistry Polymer chemistry Thiol 0210 nano-technology Cross linker |
| Zdroj: | ACS Biomaterials Science & Engineering. 3:409-419 |
| ISSN: | 2373-9878 |
| DOI: | 10.1021/acsbiomaterials.6b00663 |
| Popis: | Polymerized high internal phase emulsions (polyHIPEs) are highly porous constructs currently under investigation as tissue engineered scaffolds. We previously reported on the potential of redox-initiated polyHIPEs as injectable bone grafts that space fill irregular defects with improved integration and rapid cure. Upon subsequent investigation, the radical-initiated cure of these systems rendered them susceptible to oxygen inhibition with an associated increase in uncured macromer in the clinical setting. In the current study, polyHIPEs with increased resistance to oxygen inhibition were fabricated utilizing a tetrafunctional thiol, pentaerythritol tetrakis(3-mercaptoproprionate), and the biodegradable macromer, propylene fumarate dimethacrylate. Increased concentrations of the tetrathiol additive provided improved oxygen resistance as confirmed by polyHIPE gel fraction while retaining the requisite rapid cure rate, compressive properties, and pore architecture for use as an injectable bone graft. Additionally, thiol-methacrylate polyHIPEs exhibited increased degradation under accelerated conditions and supported critical markers of human mesenchymal stem cell activity. In summary, we have improved upon current methods of fabricating injectable polyHIPE grafts to meet translational design goals of improved polymerization kinetics under clinically relevant conditions without sacrificing key scaffold properties. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|