Antimalarials exert a cardioprotective effect in lupus patients: Insights from the Spanish Society of Rheumatology Lupus Register (RELESSER) analysis of factors associated with heart failure

Autor: Iñigo Rúa-Figueroa, David Rúa-Figueroa, Natalia Pérez-Veiga, Ana M. Anzola, María Galindo-Izquierdo, Jaime Calvo-Alén, Antonio Fernández-Nebro, Clara Sangüesa, Raúl Menor-Almagro, Eva Tomero, Natividad del Val, Esther Uriarte-Isazelaya, Ricardo Blanco, José L. Andreu, Alina Boteanu, Javier Narváez, Tatiana Cobo, Cristina Bohórquez, Carlos Montilla, Esteban Salas, Francisco J. Toyos, José A. Bernal, Eva Salgado, Mercedes Freire, Antonio J. Mas, Lorena Expósito, José A. Hernández-Beriain, Oihane Ibarguengoitia, María L. Velloso-Feijoo, Nuria Lozano-Rivas, Gemma Bonilla, Mireia Moreno, Inmaculada Jiménez, Víctor Quevedo-Vila, Angela Pecondón, Elena Aurrecoechea, Elia Valls, Coral Mouriño, Tomás Vázquez-Rodríguez, José M. Pego-Reigosa
Rok vydání: 2022
Předmět:
Zdroj: SEMINARS IN ARTHRITIS AND RHEUMATISM
r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante
instname
r-FISABIO. Repositorio Institucional de Producción Científica
Seminars in Arthritis and Rheumatism
r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol
ISSN: 0049-0172
Popis: Background/objectives: Factors associated with chronic heart failure (CHF) in patients with systemic lupus erythematosus (SLE) have received little attention. Recent data on the use of hydroxychloroquine in the treatment of SARS-CoV-2 infection have cast doubt on its cardiac safety. The factors associated with CHF, including therapy with antimalarials, were analyzed in a large multicenter SLE cohort. Methods: Cross-sectional study including all patients with SLE (ACR-1997 criteria) included in the Spanish Society of Rheumatology Lupus Register (RELESSER), based on historically gathered data. Patients with CHF prior to diagnosis of SLE were excluded. A multivariable analysis exploring factors associated with CHF was conducted. Results: The study population comprised 117 patients with SLE (ACR-97 criteria) and CHF and 3,506 SLE controls. Ninety percent were women. Patients with CHF were older and presented greater SLE severity, organ damage, and mortality than those without CHF. The multivariable model revealed the factors associated with CHF to be ischemic heart disease (7.96 [4.01-15.48], p < 0.0001), cardiac arrhythmia (7.38 [4.00-13.42], p < 0.0001), pulmonary hypertension (3.71 [1.84-7.25], p < 0.0002), valvulopathy (6.33 [3.41-11.62], p < 0.0001), non-cardiovascular damage (1.29 [1.16-1.44], p < 0.000) and calcium/vitamin D treatment (5.29 [2.07-16.86], p = 0.0015). Female sex (0.46 [0.25-0.88], p = 0.0147) and antimalarials (0.28 [0.17-0.45], p < 0.000) proved to be protective factors. Conclusions: Patients with SLE and CHF experience more severe SLE. Treatment with antimalarials appears to confer a cardioprotective effect. (c) 2021 Published by Elsevier Inc.
Databáze: OpenAIRE
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