Serum leptin levels during pregnancy in multiple sclerosis
| Autor: | Cjm de Groot, E.A.P. Steegers, Jsa Voerman, Rinze F. Neuteboom, M. Van Meurs, Jon D. Laman, Rogier Q. Hintzen, Evert Verbraak |
|---|---|
| Přispěvatelé: | Neurology, Immunology, Obstetrics & Gynecology |
| Rok vydání: | 2009 |
| Předmět: |
Adult
Leptin medicine.medical_specialty Multiple Sclerosis Enzyme-Linked Immunosorbent Assay Young Adult Pregnancy Recurrence Internal medicine medicine Humans Prospective Studies Pregnancy Trimesters Leptin receptor business.industry Multiple sclerosis Postpartum Period Case-control study medicine.disease Pregnancy Complications Endocrinology Neurology Case-Control Studies Receptors Leptin Female Neurology (clinical) business Biomarkers Postpartum period Hormone |
| Zdroj: | Multiple Sclerosis, 15(8), 907-912. SAGE Publications Ltd |
| ISSN: | 1477-0970 1352-4585 |
| DOI: | 10.1177/1352458509106515 |
| Popis: | Background Disease activity in patients with multiple sclerosis (MS) is suppressed during pregnancy, whereas attack frequency increases after delivery. It is yet unclear, which immuno – endocrinological processes mediate these disease fluctuations. Leptin has been identified as a hormone that can influence inflammatory activity. Objective The aim of this study was to investigate whether pregnancy-induced fluctuations of serum leptin levels differed between patients with MS and controls and whether serum leptin levels correlate with periods of enhanced and diminished disease activity. Methods Women with MS and healthy women were prospectively followed during and after pregnancy. The MS group could be studied already at a timepoint before pregnancy. Serum leptin and soluble leptin receptor (SLR) levels were measured using enzyme-linked immunosorbent assay. Results Pre-pregnancy serum leptin levels were (mean ± SD) 22.9 ± 12.8 ng/ml in the MS group. These levels increased in the third trimester to 28.5 ± 15.0 ng/ml ( P = 0.007). The third trimester serum leptin levels in healthy women were comparable, 29.4 ± 19.0 ng/ml. Serum leptin levels after delivery dropped to 18.5 ± 12.8 ng/ml in women with MS ( P Conclusion In women with MS, leptin increased during late pregnancy. A postdelivery drop in leptin levels was observed in both the MS and control group. The postdelivery drop was associated with the occurrence of postpartum relapse. |
| Databáze: | OpenAIRE |
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