Helicobacter pylori infection can affect energy modulating hormones and body weight in germ free mice
| Autor: | Whye Yen Wong, Shih Wee Seow, Ignatius Mario Doli Sentosa, Mun Fai Loke, Jamuna Vadivelu, Qian Hui Poh, Tuan Lin Tan, Sven Pettersson, Ralph M. Bunte, Arlaine Anne Amoyo, Kher Hsin Chiow, Yalda Khosravi |
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| Přispěvatelé: | Lee Kong Chian School of Medicine (LKCMedicine), Singapore Centre for Environmental Life Sciences Engineering |
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Chemokine CCL11
Leptin medicine.medical_specialty Peptide Hormones medicine.medical_treatment Biology Peptide hormone Weight Gain Models Biological Article Body Mass Index Helicobacter Infections Immune system Science::Biological sciences::Human anatomy and physiology [DRNTU] Internal medicine medicine Animals Humans Insulin Peptide YY Intestine Large Multidisciplinary Helicobacter pylori Microbiota biology.organism_classification Ghrelin Specific Pathogen-Free Organisms Mice Inbred C57BL Endocrinology Host-Pathogen Interactions Immunology Energy Metabolism Hormone |
| Zdroj: | Scientific Reports |
| ISSN: | 2045-2322 |
| DOI: | 10.1038/srep08731 |
| Popis: | Helicobacter pylori, is an invariably commensal resident of the gut microbiome associated with gastric ulcer in adults. In addition, these patients also suffered from a low grade inflammation that activates the immune system and thus increased shunting of energy to host defense mechanisms. To assess whether a H. pylori infection could affect growth in early life, we determined the expression levels of selected metabolic gut hormones in germ free (GF) and specific pathogen-free (SPF) mice with and without the presence of H. pylori. Despite H. pylori-infected (SPFH) mice display alteration in host metabolism (elevated levels of leptin, insulin and peptide YY) compared to non-infected SPF mice, their growth curves remained the same. SPFH mice also displayed increased level of eotaxin-1. Interestingly, GF mice infected with H. pylori (GFH) also displayed increased levels of ghrelin and PYY. However, in contrast to SPFH mice, GFH showed reduced weight gain and malnutrition. These preliminary findings show that exposure to H. pylori alters host metabolism early in life; but the commensal microbiota in SPF mice can attenuate the growth retarding effect from H. pylori observed in GF mice. Further investigations of possible additional side effects of H. pylori are highly warranted. |
| Databáze: | OpenAIRE |
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