Evaluation of certain ureas and nitrosoureas of 2,3-dihydro-1,4-benzothiazines against Sarcoma-180 solid tumors in vivo
| Autor: | Chandra Mohan Rajoria, Prashanta Kumar Dev, Mukesh Kumar Nyati, Radha Raman Gupta |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
Pharmacology
Cancer Research Nitrosourea Left flank Thiazines Positive control Antineoplastic Agents medicine.disease Mice chemistry.chemical_compound Oncology chemistry In vivo Phenothiazine Tumor Weight medicine Urea Animals Female Pharmacology (medical) Sarcoma Drug Screening Assays Antitumor Sarcoma 180 |
| Zdroj: | Anti-Cancer Drugs. 6:693-696 |
| ISSN: | 0959-4973 |
| DOI: | 10.1097/00001813-199510000-00009 |
| Popis: | Different derivatives of nitrosoureas were synthesized by a long sequence of reactions and were evaluated for their anticancer activities against female Swiss albino mice, 6-8 weeks old, weighing 18-24 g and bearing Sarcoma-180 (S-180) ascitic tumor. Experimental protocols include injecting a total of 2 x 10(5) S-180 viable ascitic cells s.c. on day 0 in the left flank of mice to obtain solid tumors, followed by the treatment of urea/nitrosourea derivatives on days 1, 5 and 9 at different dose levels. Of the 32 compounds tested, eight were found highly active against solid tumors with significant growth delay and tumor weight inhibition ratio. 5-Fluorouracil was injected s.c. as referent compound to positive control animals. |
| Databáze: | OpenAIRE |
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