Isolation and Structure Elucidation of Vicenistatin M, and Importance of the Vicenisamine Aminosugar for Exerting Cytotoxicity of Vicenistatin
| Autor: | Yoshitaka Matsushima, Kazutoshi Shindo, Renuka Bhandari, Katsumi Kakinuma, Tadashi Eguchi, Masaki Fujita, Takuya Nakayama |
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| Rok vydání: | 2001 |
| Předmět: |
Magnetic Resonance Spectroscopy
Chemical Phenomena Lactams Stereochemistry Streptomyces Structure-Activity Relationship Vicenistatin M Drug Discovery Tumor Cells Cultured Animals Humans Structure–activity relationship Vicenistatin Glycosides Cytotoxicity Hexoses Pharmacology Antibiotics Antineoplastic Molecular Structure biology Chemistry Physical Streptomycetaceae Amino Sugars biology.organism_classification Anti-Bacterial Agents Aminoglycosides Biochemistry Aminosugar Macrolides Actinomycetales Drug Screening Assays Antitumor |
| Zdroj: | The Journal of Antibiotics. 54:211-219 |
| ISSN: | 1881-1469 0021-8820 |
| DOI: | 10.7164/antibiotics.54.211 |
| Popis: | A new analogue of vicenistatin was isolated from the producing strain Streptomyces sp. HC-34. A characteristic of the elucidated structure involved the existence of a neutral sugar mycarose instead of an aminosugar vicenisamine of vicenistatin. The absolute stereochemistry of the new analogue (named as vicenistatin M) was determined by the synthesis of D-mycarose and of vicenistatin M itself. Biological testing of vicenistatin M suggested the importance of vicenisamine for exerting the cytotoxicity of vicenistatin. |
| Databáze: | OpenAIRE |
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