Role of autophagy in tumorigenesis, metastasis, targeted therapy and drug resistance of hepatocellular carcinoma
Autor: | Fang Huang, Yi-Gang Wang, Bing-Rong Wang |
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Rok vydání: | 2018 |
Předmět: |
0301 basic medicine
Carcinoma Hepatocellular Hepatocellular carcinoma Carcinogenesis medicine.medical_treatment Cellular homeostasis Antineoplastic Agents medicine.disease_cause Metastasis Targeted therapy 03 medical and health sciences 0302 clinical medicine Autophagy Animals Humans Medicine Oncolytic Virotherapy business.industry Liver Neoplasms Gastroenterology Cancer Minireviews Genetic Therapy General Medicine medicine.disease Gene Expression Regulation Neoplastic 030104 developmental biology Liver Drug Resistance Neoplasm Tumor progression Drug resistance 030220 oncology & carcinogenesis Tumorigenesis Disease Progression Hepatocytes Cancer research Beclin-1 business Liver cancer |
Zdroj: | World Journal of Gastroenterology |
ISSN: | 1007-9327 |
Popis: | Autophagy is a "self-degradative" process and is involved in the maintenance of cellular homeostasis and the control of cellular components by facilitating the clearance or turnover of long-lived or misfolded proteins, protein aggregates, and damaged organelles. Autophagy plays a dual role in cancer, including in tumor progression and tumor promotion, suggesting that autophagy acts as a double-edged sword in cancer cells. Liver cancer is one of the greatest leading causes of cancer death worldwide due to its high recurrence rate and poor prognosis. Especially in China, liver cancer has become one of the most common cancers due to the high infection rate of hepatitis virus. In primary liver cancer, hepatocellular carcinoma (HCC) is the most common type. Considering the perniciousness and complexity of HCC, it is essential to elucidate the function of autophagy in HCC. In this review, we summarize the physiological function of autophagy in cancer, analyze the role of autophagy in tumorigenesis and metastasis, discuss the therapeutic strategies targeting autophagy and the mechanisms of drug-resistance in HCC, and provide potential methods to circumvent resistance and combined anticancer strategies for HCC patients. |
Databáze: | OpenAIRE |
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