Synthesis and structure-activity relationships of new non-steroidal progesterone receptor ligands
| Autor: | Kiyoshi Tanabe, Kenichi Kurihara, Rie Shinei, Okonogi Tsuneo, Keiichi Ajito, Yasuo Yamamoto |
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| Rok vydání: | 1999 |
| Předmět: |
chemistry.chemical_classification
Stereochemistry Organic Chemistry Clinical Biochemistry Penicillium Pharmaceutical Science Naphthols Ligands Biochemistry Chemical synthesis Non steroidal In vitro chemistry.chemical_compound Kinetics Structure-Activity Relationship chemistry Drug Discovery Progesterone receptor Molecular Medicine Furans Receptors Progesterone Molecular Biology Sesquiterpenes Lactone Methyl group |
| Zdroj: | Bioorganicmedicinal chemistry letters. 9(13) |
| ISSN: | 0960-894X |
| Popis: | In order to study structure-activity relationships, a series of new non-steroidal progesterone receptor ligands based on PF1092A 1) was synthesized with structural modifications (mostly introduction or removal of a methyl group) at the 3-, 4-, 5-, 7- or 9-position in the 6-acetoxy-4a, 5, 6, 7-tetrahydro-3, 4a, 5-trimethylnaphtho[2, 3 - b ]furan-2(4 H )-one 2) skeleton. Critical positions for high binding affinity to the progesterone receptor were identified. |
| Databáze: | OpenAIRE |
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