Imaging of dopamine transporters and D2 receptors in patients with Parkinson's disease and multiple system atrophy

Autor: Merete Karlsborg, K. S. Krabbe, Gerda Thomsen, Lisbeth Regeur, Lene Werdelin, T. Nygaard, Charlotte Videbæk, Gitte M. Knudsen
Rok vydání: 2004
Předmět:
Adult
Male
medicine.medical_specialty
Pathology
Parkinson's disease
Pyrrolidines
Nerve Tissue Proteins
Gastroenterology
Sensitivity and Specificity
Diagnosis
Differential
Iodine Radioisotopes
Atrophy
Cocaine
Dopamine
Dopamine receptor D2
Internal medicine
parasitic diseases
mental disorders
medicine
Humans
Radiology
Nuclear Medicine and imaging
Receptor
Dopamine transporter
Aged
Tomography
Emission-Computed
Single-Photon
Dopamine Plasma Membrane Transport Proteins
Membrane Glycoproteins
biology
business.industry
Receptors
Dopamine D2
Parkinsonism
Dopaminergic
Brain
Membrane Transport Proteins
Reproducibility of Results
Parkinson Disease
General Medicine
Middle Aged
Multiple System Atrophy
bacterial infections and mycoses
medicine.disease
nervous system
Benzamides
biology.protein
Female
Radiopharmaceuticals
business
medicine.drug
Zdroj: European journal of nuclear medicine and molecular imaging. 31(12)
ISSN: 1619-7070
Popis: The aim of this study was to ascertain whether combined presynaptic and postsynaptic dopaminergic single-photon emission computed tomography (SPECT) scanning is useful for differentiation between patients with idiopathic Parkinson's disease (IPD), patients with multiple system atrophy of the striatonigral type (MSA) and healthy subjects.SPECT measurements of the dopamine transporter (DAT) were done with 123I-beta-CIT, while for determination of the dopamine D2-like receptors (D2), 123I-epidepride was used. Clinical evaluation and SPECT scans were carried out in 14 patients with IPD, eight patients with MSA and 11 healthy age-matched control subjects.Putaminal DAT binding was reduced to 32% of control values in IPD and to 19% of control values in MSA . Significantly higher striatal asymmetry in DAT binding was found in MSA than in controls, but IPD patients had significantly higher asymmetry than MSA patients. Striatal D2 binding did not differ significantly between patients and healthy controls but the ratio between caudate DAT and D2 binding was significantly higher in patients with IPD than in those with MSA, even when disease severity was taken into account.Patients with reduced striatal 123I-beta-CIT binding and a side-to-side difference greater than 15% are likely to suffer from IPD. Patients with reduced striatal 123I-beta-CIT binding and a side-to-side difference of between 5% and 15% are more likely to have MSA. 123I-epidepride SPECT measurements may add further diagnostic information, since the ratio between DAT and D2 receptor binding is significantly higher in IPD than in MSA.
Databáze: OpenAIRE
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