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Background: Peri-implant disease is a condition of pathological inflammation that develop in the tissue surrounding a load-bearing implant which can lead to loss of the implant itself. Anaerobic plaque bacteria are considered risk factor with negative impacts on the peri-implant tissue health leading to peri-implantitis. Air polishing technique which first introduced as an alternative technique for removing biofilm and supragingival extrinsic stain. Aims: define Air polishing technique and indicate the different between peri-implant mucositis and peri-implantitis and the risk factors related to them besides, evaluate the effectiveness of glycine powder air polishing on treatment of peri-implantitis. Methodology: we depend on systemic review exploring different medical online databases about peri-implantitis and Air polishing techniques in any studies published from 2000 until 2019. Results: 10 articles were included in the qualitative synthesis of the present review, three studies were systemic reviews, two studies were articles, one was an observational clinical trial and 4 studies were randomized Clinical Trial. Conclusion: Peri-implantitis is one of the most complication of implant which has biological source considering that plaque is the most risk factors of peri-implantitis. Peri-implantitis occurrence is considering a critical risk factors of the success of the implant which can be a cause of implant loss if untreated. Different technique used to decontaminate the implant to prevent the infection and used also in treatment of peri-implantitis through complete debridement and removal of bacteria biofilm which have critical role in removing plaque. Air polishing seems to have a positive effect on improving oral hygiene of tissue surrounding the implant and decontaminate the implant of further plaque. Moreover, we found that air polishing using glycine powder is an effective way to remove the plaque, treatment of inflammation, improving oral hygiene and reducing bleeding on probing (BOP) with minimum side effect and prefect patients' compliance. However, we recommend further investigation to evaluate other powder than glycine powder and their effect on peri-implantitis. Moreover, further investigation should include exploring different factors affecting the efficiency of air polishing and factors that affect the success of implant itself.  |