The Efficacy and Safety of High-dose Daptomycin in the Treatment of Complicated Skin and Soft Tissue Infections in Asians
| Autor: | Yanyan Guan, Xiaomeng Dong, Qing-yan Li, Feng Zheng, Fengzhe Chen, Yongyuan Yao, Gang Wang, Nannan Xu |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
Male 0301 basic medicine Microbiology (medical) China medicine.medical_specialty Multivariate analysis Adolescent Demographics 030106 microbiology High-dose lcsh:Infectious and parasitic diseases Young Adult 03 medical and health sciences 0302 clinical medicine Daptomycin Internal medicine medicine Humans lcsh:RC109-216 030212 general & internal medicine Adverse effect Clinical treatment Aged Aged 80 and over Cross Infection business.industry Soft Tissue Infections Complicated Infection Incidence (epidemiology) Soft tissue Skin Diseases Bacterial General Medicine Middle Aged Anti-Bacterial Agents Treatment Outcome Infectious Diseases Asian population Female Safety business medicine.drug |
| Zdroj: | International Journal of Infectious Diseases, Vol 95, Iss, Pp 38-43 (2020) |
| ISSN: | 1201-9712 |
| Popis: | Objective: To compare the efficacy and safety of standard-dose (SD) daptomycin with those of high-dose (HD) daptomycin in complicated skin and soft tissue infections (cSSTIs) in an Asian population. Materials and Methods: Patients from three medical centers diagnosed with cSSTIs were screened in the clinical information system. Patients included in the analysis were divided into two groups: those who received daptomycin at doses ≥ 6 mg/kg (HD group) and those receiving 4 mg/kg (SD group). The demographics and clinical treatment information were analyzed. Results: Overall, 155 patients were recruited, including 108 patients in the SD group and 47 patients in the HD group. The rate of healthcare-associated infections was higher in the HD group (61.70% vs. 37.04%), demonstrating a statistically significant difference (P = 0.005). Compared with the SD group, the HD group had statistically significant early clinical stabilization (72.34% vs 52.78%, P = 0.023). The results of the multivariate analysis indicated that HD daptomycin was an independent effector for early clinical stabilization (HR=0.394, P |
| Databáze: | OpenAIRE |
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