Cactin, a conserved protein that interacts with the Drosophila IkappaB protein cactus and modulates its function
| Autor: | Pei Hui Lin, Leslie H. Huang, Ruth Steward |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Embryology
Heterozygote Embryo Nonmammalian Molecular Sequence Data Biology Conserved sequence Evolution Molecular Two-Hybrid System Techniques Animals Drosophila Proteins Humans Amino Acid Sequence Transcription factor Peptide sequence Fetal Death Conserved Sequence Genetics Regulation of gene expression Sequence Homology Amino Acid Ovary Gene Expression Regulation Developmental Phosphoproteins Phenotype Precipitin Tests DNA-Binding Proteins Insect Proteins Drosophila Female I-kappa B Proteins Signal transduction Carrier Proteins Function (biology) Drosophila Protein Developmental Biology |
| Zdroj: | Mechanisms of development. 94(1-2) |
| ISSN: | 0925-4773 |
| Popis: | Rel transcription factors function in flies and vertebrates in immunity and development. Although Rel proteins regulate diverse processes, the control of their function is conserved. In a two-hybrid screen for additional components of the pathway using the Drosophila I-kappaB protein Cactus as a bait, we isolated a novel coiled-coil protein with N-terminal Arg-Asp (RD)- like motifs that we call Cactin. Like the other components of this pathway, Cactin is evolutionarily conserved. Over-expression of cactin in a cactus(A2) heterozygous background results in the enhancement of the cactus phenotype. Both the embryonic lethality and ventralization are strongly increased, suggesting that cactin functions in the Rel pathway controlling the formation of dorsal-ventral embryonic polarity. |
| Databáze: | OpenAIRE |
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