Impact of Pneumococcal Vaccination in the Nasopharyngeal Carriage of Streptococcus pneumoniae in Healthy Children of the Murcia Region in Spain
| Autor: | Santiago Alfayate Miguélez, Genoveva Yague Guirao, Ana I. Menasalvas Ruíz, Manuel Sanchez-Solís, Mirian Domenech Lucas, Fernando González Camacho, M. Mar Ortíz Romero, Pilar Espejo García, Carmen Guerrero Gómez, Antonio Iofrío de Arce, Laura Moreno Parrado, Rosa M. Sánchez Andrada, Eva Cascales Alcolea, Sebastián Lorente García, Pedro Paredes Reyes, Ángela Casquet Barceló, M. Luisa López Yepes, Juan José Vigueras Abellán, Gonzalo Sanz Mateo, Murcian Pneumococcal Study Group |
|---|---|
| Přispěvatelé: | Ministerio de Economía y Competitividad (España) |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty 030106 microbiology Immunology Erythromycin lcsh:Medicine medicine.disease_cause Antimicrobial susceptibility Article Pneumococcal conjugate vaccine antimicrobial susceptibility 03 medical and health sciences 0302 clinical medicine conjugate vaccines Internal medicine Drug Discovery Streptococcus pneumoniae medicine Pharmacology (medical) 030212 general & internal medicine Streptococcus pneumoniae nasopharyngeal carriage Pharmacology business.industry Sulfamethoxazole lcsh:R Trimethoprim Conjugate vaccines Vaccination Penicillin Infectious Diseases Carriage business medicine.drug |
| Zdroj: | Vaccines, Vol 9, Iss 14, p 14 (2021) Vaccines Volume 9 Issue 1 Repisalud Instituto de Salud Carlos III (ISCIII) |
| Popis: | An epidemiological study of Streptococcus pneumoniae nasopharyngeal carriage in healthy children was carried out five years after the introduction of the 13-valent pneumococcal conjugate vaccine (PCV13). Study the impact of pediatric vaccination with PCV13, and other associated epidemiological factors on the status of nasopharyngeal carriage, the circulating pneumococcal serotypes, and the antibiotic susceptibility to more frequently used antibiotics. A multi-center study was carried out in Primary Health Care, which included 1821 healthy children aged 1 to 4 years old. All isolates were sent to the Spanish Pneumococcal Reference Laboratory for serotyping and antimicrobial susceptibility testing. At least one dose of PCV13 had been received by 71.9% of children and carriage pneumococcal prevalence was 19.7%. The proportion of PCV13 serotypes was low (14.4%), with an observed predominance of non-vaccine serotypes, 23B, 11A, 10A, 35B/F, and 23A were the five most frequent. A high rate of resistance to penicillin, erythromycin, and trimethoprim sulfamethoxazole was found. A low proportion of PCV13 serotypes were detected, confirming the impact of pediatric vaccination for reducing the serotypes vaccine carriage. High resistance rates to clinically important antibiotics were observed. This work was supported by Ministerio de Economía, Industria y Competitividad (MINECO)[grant SAF2017-83388]. Sí |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|