Animal Models of Hepatocellular Carcinoma Prevention
| Autor: | Massimo Negrini, Silvia Sabbioni, Elisa Callegari, Ram C. Shankaraiah, Laura Gramantieri, Francesca Fornari |
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| Přispěvatelé: | Shankaraiah R.C., Gramantieri L., Fornari F., Sabbioni S., Callegari E., Negrini M. |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Oncology Cancer Research medicine.medical_specialty Socio-culturale Context (language use) Tumor initiation Disease Review Chronic liver disease medicine.disease_cause 03 medical and health sciences 0302 clinical medicine prevention Internal medicine medicine Animal model neoplasms Tumor microenvironment business.industry hepatocellular carcinoma medicine.disease digestive system diseases animal models Long latency 030104 developmental biology 030220 oncology & carcinogenesis Hepatocellular carcinoma business Carcinogenesis Animal models Hepatocellular carcinoma Prevention |
| Zdroj: | Cancers |
| ISSN: | 2072-6694 |
| Popis: | Hepatocellular carcinoma (HCC) is a deadly disease and therapeutic efficacy in advanced HCC is limited. Since progression of chronic liver disease to HCC involves a long latency period of a few decades, a significant window of therapeutic opportunities exists for prevention of HCC and improve patient prognosis. Nonetheless, there has been no clinical advancement in instituting HCC chemopreventive strategies. Some of the major challenges are heterogenous genetic aberrations of HCC, significant modulation of tumor microenvironment and incomplete understanding of HCC tumorigenesis. To this end, animal models of HCC are valuable tools to evaluate biology of tumor initiation and progression with specific insight into molecular and genetic mechanisms involved. In this review, we describe various animal models of HCC that facilitate effective ways to study therapeutic prevention strategies that have translational potential to be evaluated in a clinical context © 2019 by the authors. Licensee MDPI, Basel, Switzerland. |
| Databáze: | OpenAIRE |
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