Synthesis, characterization and biological activity of some platinum(II) complexes with Schiff bases derived from salicylaldehyde, 2-furaldehyde and phenylenediamine
| Autor: | Akmal S. Gaballa, Atiat S. Barakat, Mohsen S. Asker, Said M. Teleb |
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| Rok vydání: | 2007 |
| Předmět: |
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Molecular Antifungal Agents Stereochemistry chemistry.chemical_element Platinum Compounds Microbial Sensitivity Tests Saccharomyces cerevisiae Phenylenediamines Ligands Medicinal chemistry Analytical Chemistry Metal chemistry.chemical_compound Ultraviolet visible spectroscopy Candida albicans Molecule Furaldehyde Thermal analysis Instrumentation Schiff Bases Spectroscopy Aldehydes Schiff base Bacteria Atomic and Molecular Physics and Optics Anti-Bacterial Agents Aspergillus chemistry Salicylaldehyde visual_art visual_art.visual_art_medium Platinum |
| Zdroj: | Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy. 67:114-121 |
| ISSN: | 1386-1425 |
| Popis: | Four platinum(II) complexes of Schiff bases derived from salicylaldehyde and 2-furaldehyde with o- and p-phenylenediamine were reported and characterized based on their elemental analyses, IR and UV-vis spectroscopy and thermal analyses (TGA). The complexes were found to have the general formula [Pt(L)(H(2)O)(2)]Cl(2) x nH(2)O (where n=0 for complexes 1, 3, 4; n=1 for complex 2. The data obtained show that Schiff bases were interacted with Pt(II) ions in the neutral form as a bidentate ligand and the oxygens rather than the nitrogens are the most probable coordination sites. Square planar geometrical structure with two coordinated water molecules were proposed for all complexes The free ligands, and their metal complexes were screened for their antimicrobial activities against the following bacterial species: E. coli, B. subtilis, P. aereuguinosa, S. aureus; fungus A. niger, A. fluves; and the yeasts C. albican, S. cervisiea. The activity data show that the platinum(II) complexes are more potent antimicrobials than the parent Schiff base ligands against one or more microorganisms. |
| Databáze: | OpenAIRE |
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