Whether drug detection in urine and oral fluid is similar? A systematic review
| Autor: | Alexandre R. Vieira, Luciana Reis Azevedo-Alanis, Milena Binhame Albini Martini, Thiago Beltrami Dias Batista, Patricia Tolentino da Rosa de Souza, Indiara Welter Henn |
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| Rok vydání: | 2020 |
| Předmět: |
Drug
Saliva media_common.quotation_subject Street drugs Urine 010501 environmental sciences Pharmacology Toxicology 01 natural sciences Drug detection Matrix (chemical analysis) 03 medical and health sciences Medicine Humans 030304 developmental biology 0105 earth and related environmental sciences media_common 0303 health sciences business.industry Illicit Drugs Substance Abuse Detection stomatognathic diseases Oral fluid business |
| Zdroj: | Critical reviews in toxicology. 50(4) |
| ISSN: | 1547-6898 |
| Popis: | Urine has been a biological matrix of choice for drug screening, but recent advances in technology and the introduction of commercial oral fluid assays have effectively established oral fluid as a viable alternative matrix. This systematic review aimed to evaluate the sensitivity of oral fluid in detecting some illicit drugs compared to urine, and to compare the initial and final detection times of these drugs in both fluids. The electronic search in MEDLINE, Cochrane Library, Scopus, and Web of Science was carried out covering studies published from January 2003 and June 2019, in order to find all valid studies that detected drugs in oral fluid and urine in the same patient. Studies about illicit drugs, such as tetrahydrocannabinol, cocaine, amphetamines and illicit opioids, with fluids collection at the same day, controlled drug administration during the study, reported administration interval and time of collection were favored. Out of 2598 studies identified by electronic search, 7 studies were selected for qualitative analysis. Five were clinical trials and 2 were crossover trials. In total, 74 patients aged 20-52 years underwent a diagnostic examination (4 studies with tetrahydrocannabinol, 1 with methamphetamine, and 2 with cocaine) after drug administration. Illicit drug detection in oral fluid is similar to urine but oral fluid has a strong potential for the immediate detection of recent marijuana use compared to urine. In relation to cocaine and methamphetamine, the largest drugs detection window is obtained through urine analysis. Oral fluids cannot replace urine for most of the purposes of drug testing. |
| Databáze: | OpenAIRE |
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