A Novel Device-Integrated Drug Delivery System for Local Inhibition of Urinary Tract Infection
| Autor: | Yaseelan Palarasah, Rasmus Birkholm Grønnemose, Martin Alm, Lars Lund, Peter Thomsen, Thomas Emil Andersen, Kristian Stærk, Hans Jørn Kolmos |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Microbiology (medical)
medicine.medical_specialty Urinary system Urology large animal model Balloon Microbiology 03 medical and health sciences chemistry.chemical_compound Silicone medicine drug release 030304 developmental biology Original Research interpenetrating polymer network 0303 health sciences Urinary bladder uropathogenic Escherichia coli urinary catheter 030306 microbiology business.industry Biofilm Antimicrobial QR1-502 Catheter medicine.anatomical_structure chemistry Drug delivery business CAUTI |
| Zdroj: | Frontiers in Microbiology Frontiers in Microbiology, Vol 12 (2021) Stærk, K, Grønnemose, R B, Palarasah, Y, Kolmos, H J, Lund, L, Alm, M, Thomsen, P & Andersen, T E 2021, ' A Novel Device-Integrated Drug Delivery System for Local Inhibition of Urinary Tract Infection ', Frontiers in Microbiology, vol. 12, 685698 . https://doi.org/10.3389/fmicb.2021.685698 |
| ISSN: | 1664-302X |
| Popis: | Background: Catheter-associated urinary tract infection (CAUTI) is a frequent community-acquired infection and the most common nosocomial infection. Here, we developed a novel antimicrobial catheter concept that utilizes a silicone-based interpenetrating polymer network (IPN) as balloon material to facilitate a topical slow-release prophylaxis of antibacterial agents across the balloon to the urinary bladder.Methods: The balloon material was achieved by modifying low shore hardness silicone tubes with a hydrogel interpenetrating polymer in supercritical CO2 using the sequential method. Release properties and antibacterial efficacy of the IPN balloon treatment concept was investigated in vitro and in a porcine CAUTI model developed for the study. In the latter, Bactiguard Infection Protection (BIP) Foley catheters were also assessed to enable benchmark with the traditional antimicrobial coating principle.Results: Uropathogenic Escherichia coli was undetectable in urinary bladders and on retrieved catheters in the IPN treatment group as compared to control that revealed significant bacteriuria (>105 colony forming units/ml) as well as catheter-associated biofilm. The BIP catheters failed to prevent E. coli colonization of the bladder but significantly reduced catheter biofilm formation compared to the control.Conclusion: The IPN-catheter concept provides a novel, promising delivery route for local treatment in the urinary tract. |
| Databáze: | OpenAIRE |
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