Breast cancer subtypes affect the ultrasound performance for axillary lymph node status evaluation after neoadjuvant chemotherapy: a retrospective analysis
| Autor: | Jin Zhu Ma, Jie Fei, Jing Jing Chen, Yuan Yuan Meng, Ning Ning Sun, Xin Zhong, Guan Qun Wang |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Oncology
Cancer Research medicine.medical_specialty medicine.medical_treatment Breast Neoplasms Breast cancer Internal medicine medicine Retrospective analysis Humans Radiology Nuclear Medicine and imaging Lymph node Pathological Retrospective Studies Ultrasonography Axillary ultrasound Chemotherapy Sentinel Lymph Node Biopsy business.industry Ultrasound General Medicine medicine.disease Neoadjuvant Therapy Exact test medicine.anatomical_structure Lymphatic Metastasis Axilla Female Lymph Nodes business |
| Zdroj: | Japanese Journal of Clinical Oncology. 51:1509-1514 |
| ISSN: | 1465-3621 |
| DOI: | 10.1093/jjco/hyab117 |
| Popis: | Purpose The aim of our study was to investigate the effect of breast cancer subtypes on the diagnostic value of axillary ultrasound for node status evaluation after neoadjuvant chemotherapy. Patients and methods Pathologic node-positive breast cancer patients underwent axillary ultrasound imaging after neoadjuvant chemotherapy were retrospectively reviewed. The enrolled patients were classified into four subtypes: Luminal A, Luminal B, human epidermal growth factor receptor 2-enriched and triple-negative. Ultrasound images of axillary nodes were reviewed and were evaluated as normal or abnormal and were associated with final pathologic results. Diagnostic value of axillary ultrasound was assessed in four subtypes based on sensitivity, specificity, positive predictive value and negative predictive value. The diagnostic value of axillary ultrasound as well as clinical and pathological characteristics was compared between four breast cancer subtypes using chi-square test or fisher’s exact test. Result Luminal A subtype had highest positive predictive value (92.1%), lowest sensitivity (43.8%) and lowest negative predictive value (11.8%). Triple-negative subtype had lowest positive predictive value (73.2%), highest sensitivity (76.9%) and highest negative predictive value (59.1%) (P Conclusion The diagnostic value of axillary ultrasound for node residue disease assessment after neoadjuvant chemotherapy is different between four breast cancer subtypes. |
| Databáze: | OpenAIRE |
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