Role of Peroxide in Phagocytic Killing of Pneumococci
| Autor: | Harriet P. Bernheimer, Jane Pitt |
|---|---|
| Rok vydání: | 1974 |
| Předmět: |
Male
Blood Bactericidal Activity Immunology Population Mutant Biology Microbiology Peroxide chemistry.chemical_compound Chronic granulomatous disease Phagocytosis Leukocytes medicine Animals Humans In patient education education.field_of_study Strain (chemistry) Immune Sera Wild type medicine.disease Virology Peroxides Streptococcus pneumoniae Infectious Diseases chemistry Bacterial Vaccines Phagocyte Bactericidal Dysfunction Pathogenic Mechanisms Ecology and Epidemiology Parasitology Rabbits Phagocytic vacuole |
| Zdroj: | Infection and Immunity. 9:48-52 |
| ISSN: | 1098-5522 0019-9567 |
| DOI: | 10.1128/iai.9.1.48-52.1974 |
| Popis: | Two mutants of a pneumococcus type I with diminished peroxide production were selected from a population of nitrosoguanidine-treated cells. White cells of normal patients killed the mutant pneumococci as well as the otherwise isogenic wild-type strain. In patients studied with chronic granulomatous disease, however, the peroxide-poor strain was killed far less well than the wild type. These studies indicate that the removal of a peroxide-generating system in the phagocytic vacuole specifically brings forth the killing defect in chronic granulomatous disease. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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